Tetrazine-mPEG
Cat No.: BP-502179
4.5 
Tetrazine-mPEG is an mPEG-based linker reagent incorporating a tetrazine functionality, providing a chemically stable, water-compatible scaffold for constructing PROTACs and related targeted degradation conjugates. Structurally, it combines a polyethylene glycol chain with a tetrazine moiety that can undergo rapid inverse-electron-demand Diels–Alder ligation with trans-cyclooctene or related strained dienes, enabling site-specific attachment under mild conditions. In PROTAC design, this tetrazine–diene “click” strategy allows researchers to modularly assemble bifunctional degraders by conjugating a targeting ligand and an E3-recruiting element through a defined linker, improving control over spatial arrangement and functional group tolerance. The PEG component can enhance aqueous solubility and reduce nonspecific interactions, which is advantageous for preparing and screening degradation constructs. Overall, Tetrazine-mPEG supports efficient, modular synthesis and reliable conjugation workflows for targeted protein degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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Tetrazine-mPEG is a polyethylene glycol (mPEG) functionalized tetrazine linker designed for modular incorporation into PROTAC architectures that benefit from bioorthogonal click chemistry. Its tetrazine motif enables fast, selective inverse-electron-demand Diels–Alder ligation, while the PEG segment can improve solubility and tune conjugate behavior in aqueous media. The combination supports efficient assembly of targeted degradation constructs; the following points describe its structure and practical reactivity considerations in detail below.
Structure: Tetrazine-mPEG contains a tetrazine core conjugated to an mPEG chain, providing an electron-deficient dienophile for bioorthogonal ligation. The molecule features heteroaromatic nitrogen-rich functionality and a flexible ether-rich PEG backbone, yielding amphiphilic behavior and improved aqueous compatibility.
Reactivity: Tetrazine-mPEG is used in PROTAC assembly via inverse-electron-demand Diels–Alder reactions with appropriate strained dienophiles (commonly trans-cyclooctene or related alkenes). Reactions are typically performed under mild, aqueous-compatible conditions to preserve protein-ligand integrity, using standard buffer systems and avoiding strongly nucleophilic or highly reducing environments that could interfere with tetrazine stability. No special catalysts are generally required because the ligation proceeds through rapid pericyclic reactivity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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