Tetrazine-Ph-NHCO-PEG6-NH-Boc
Cat No.: BP-502026
4.5 
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a bifunctional, PEG-based PROTAC linker featuring a tetrazine handle for rapid inverse-electron-demand Diels–Alder bioorthogonal conjugation, a phenyl spacer, and a urethane/amide connectivity that supports stable attachment to complementary PROTAC fragments. The PEG6 segment provides a flexible, hydrophilic tether that can reduce steric constraints and help position the recruited ligands at an optimal distance and orientation for productive ternary complex formation with the target protein and the E3 ligase-binding moiety. In targeted protein degradation workflows, this linker is used to connect or exchange warheads and ligase recruiters via tetrazine-mediated chemoselective ligation, enabling modular assembly of degradation constructs under mild conditions. Its PEG architecture and orthogonal tetrazine reactivity make it particularly valuable for designing degraders that require controlled linker length, improved solubility, and efficient conjugation for structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This Tetrazine-Ph-NHCO-PEG6-NH-Boc linker is designed for modular PROTAC assembly, combining a tetrazine handle with a flexible polyethylene glycol spacer and protected amine functionality. Its structural features support efficient conjugation to targeting ligands and facilitate formation of productive ternary-complex inducing degraders. The linker’s balanced flexibility and chemical stability help maintain linker reach and reduce steric constraints, while the tetrazine motif enables bioorthogonal conjugation strategies. Detailed structural and synthetic considerations are provided below.
Structure: The linker contains a tetrazine-containing aromatic system connected through a phenyl spacer to a carbamate-forming amide linkage and a PEG-based chain. It incorporates multiple heteroatoms (nitrogen and oxygen) that provide polarity, hydrogen-bonding capacity, and conformational flexibility typical of PEG linkers.
Reactivity: Tetrazine functionality is suitable for inverse-electron-demand Diels–Alder conjugation with strained dienes/tetrazines-compatible partners under mild, aqueous-compatible conditions commonly used in bioorthogonal labeling. The Boc-protected amine can be deprotected using standard acid-mediated conditions to reveal a reactive amine for amide or urea coupling. Amide bond formation is typically performed with activated carboxylic acids or coupling reagents in polar organic solvents with base, following established PROTAC linker-conjugation workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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