Thiol-PEG10-alcohol
Cat No.: BP-502057
Purity: >95%
4.5 
Thiol-PEG10-alcohol is a monofunctional polyethylene glycol (PEG) linker bearing a terminal thiol and a terminal hydroxyl group, providing a flexible, hydrophilic chain that can be used to space and solubilize PROTAC components. The PEG segment acts as a conformational buffer between the warhead/ligand and the conjugation handle, reducing steric interference and often improving aqueous compatibility during synthesis and biological testing. Its terminal thiol enables chemoselective attachment to electrophilic partners (for example, maleimide- or haloacetamide-activated groups) or incorporation into thiol–disulfide exchange strategies, thereby facilitating controlled assembly of bifunctional degraders. In targeted protein degradation research, such linkers are valuable for tuning the effective distance and orientation required for productive ternary complex formation, while the hydroxyl terminus can further support downstream derivatization or formulation. This reagent is therefore useful for constructing and optimizing PROTAC architectures that require robust, water-compatible linker chemistry.
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* For research and manufacturing use only. Not for human or clinical use.
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Thiol-PEG10-alcohol is a polyethylene glycol (PEG)-based linker designed for modular construction of PROTACs, enabling controlled spatial separation and improved solubility between a ligand and an E3-recruiting or target-binding moiety. Its terminal thiol functionality supports chemoselective conjugation strategies commonly used in targeted protein degradation workflows. The combination of a flexible PEG scaffold and a reactive sulfur handle offers practical advantages for assembling degraders with reproducible linker geometry; detailed structural and reactivity considerations are provided below.
Structure: The molecule features a PEG chain terminated with an alcohol and a thiol group, providing a flexible, hydrophilic spacer. It contains ether linkages characteristic of PEG, along with a terminal thiol that can participate in thiol–reactive coupling chemistry. The overall structure supports aqueous compatibility and conformational adaptability.
Reactivity: The terminal thiol enables conjugation via thiol-reactive electrophiles used in PROTAC assembly, including maleimide- or haloacetamide-type coupling partners, typically under mild, buffered conditions that preserve thiol integrity. To minimize thiol oxidation, reactions are commonly performed under inert or reducing atmospheres and with thiol-stabilizing additives where appropriate. Solvent systems such as aqueous-organic mixtures are often used to balance solubility of ligands and coupling efficiency, following established chemoselective conjugation principles.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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