Thiol-PEG12-alcohol
Cat No.: BP-501979
Purity: >95%
4.5 
Thiol-PEG12-alcohol is a polyethylene glycol (PEG) linker bearing a terminal thiol and a terminal hydroxyl, providing a flexible, hydrophilic spacer of approximately twelve ethylene oxide units between conjugation sites. The PEG chain length and ether-rich backbone help reduce steric hindrance and improve aqueous solubility, while the thiol functionality enables chemoselective attachment to electrophilic handles (e.g., maleimides, activated disulfides, or other thiol-reactive groups) commonly used in PROTAC assembly workflows. In targeted protein degradation constructs, this type of bifunctional linker can serve as a “molecular tether” that spatially positions a ligand for a target protein relative to an E3 ligase recruiter, thereby facilitating formation of the ternary complex and supporting productive ubiquitination. Its alcohol terminus can also be used for further derivatization or to tune polarity and reactivity. Overall, Thiol-PEG12-alcohol is a practical building block for designing and optimizing PROTAC linkers where controlled flexibility and solubility are critical for degradation performance.
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* For research and manufacturing use only. Not for human or clinical use.
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Thiols and PEG-based spacers are widely used in PROTAC linker design to tune solubility, conformational flexibility, and the effective distance between a target-binding ligand and an E3 ligase recruiter. Thiol-PEG12-alcohol provides a functional handle for controlled conjugation chemistry while maintaining a hydrophilic, biocompatible polymeric environment that can improve coupling efficiency and facilitate downstream purification. The points below describe its structural features and practical considerations for PROTAC assembly in detail.
Structure: Thiol-PEG12-alcohol is a polyethylene glycol–based linker bearing a terminal thiol and a terminal alcohol. Its backbone consists of repeating ether units, providing a flexible, hydrophilic scaffold. The molecule contains a reactive thiol group capable of forming thioether linkages, alongside an alcohol that can participate in standard derivatization chemistry.
Reactivity: The terminal thiol enables conjugation via thiol–maleimide or thiol–disulfide exchange strategies, as commonly used to install PROTAC warheads or to couple ligands through thioether formation. Typical conditions employ aqueous or mixed aqueous/organic solvents at mild temperature, with pH control to preserve thiol nucleophilicity and minimize oxidation. For thiol–disulfide approaches, reducing agents and oxygen exclusion are often used to manage redox equilibria, while maleimide coupling generally benefits from rapid, nucleophile-efficient conditions to drive selective adduct formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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