THP-PEG10-OH
Cat No.: BP-501933
4.5 
THP-PEG10-OH is a polyethylene glycol linker bearing a terminal hydroxyl group and a THP (tetrahydropyran) protecting group, providing a flexible, hydrophilic spacer commonly used in PROTAC and targeted protein degradation construct assembly. Structurally, it consists of a PEG chain of intermediate length that can improve aqueous solubility and reduce nonspecific hydrophobic interactions, while the THP group allows controlled functional group handling during synthesis and subsequent deprotection to reveal reactive sites for conjugation. In PROTAC design, such PEG linkers help position the E3 ligase-binding ligand and the target-binding moiety at an appropriate distance and orientation to promote productive ternary complex formation and ubiquitination. As a modular building block, THP-PEG10-OH supports systematic linker optimization, enabling researchers to tune degradation potency and selectivity through linker length and attachment chemistry while maintaining compatibility with standard peptide/ligand coupling workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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THP-PEG10-OH is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by providing a flexible, hydrophilic spacer between a ligand and an E3-recruiting moiety. Its ether-rich backbone can enhance solubility and reduce steric constraints, often improving the effective presentation of binding groups. The linker is well suited for synthetic strategies that require a terminal hydroxyl handle for subsequent conjugation steps; detailed structural and reactivity considerations are provided below.
Structure: THP-PEG10-OH comprises a PEG chain featuring repeating ether linkages and a terminal hydroxyl group. The structure is dominated by flexible C–O ether bonds, with a hydrophobic THP (tetrahydropyran) segment that can modulate local polarity. Overall, it is expected to be conformationally flexible and water-compatible.
Reactivity: The terminal hydroxyl enables common PROTAC linker functionalization routes such as conversion to activated derivatives for nucleophilic substitution or coupling to complementary electrophiles on ligands. Typical approaches include etherification or esterification under standard organic synthesis conditions, using appropriate coupling reagents and bases to drive formation of stable linkages. Solvent systems are selected to solubilize both partners while preserving PEG integrity; reaction temperatures are kept mild to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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