THP-PEG8-alcohol
CAS No.: 658858-65-2
Cat No.: BP-501332
Purity: >95%
4.5 
THP-PEG8-alcohol is a polyethylene glycol–based linker bearing a terminal alcohol functionality, designed for modular conjugation in PROTAC and targeted protein degradation constructs. Structurally, it provides a flexible, hydrophilic PEG chain of intermediate length that can spatially separate a ligand-derived warhead from an E3-recruiting moiety, reducing steric clashes and helping maintain productive ternary complex formation. The terminal alcohol enables straightforward chemical derivatization (for example, conversion to activated carbonate/ester or ether formation) to attach the linker to functional groups on coupling partners under standard bioconjugation conditions. In PROTAC design, such PEG linkers are widely used to tune linker length, polarity, and conformational freedom, which can materially influence cellular uptake, degradation potency, and degradation selectivity by altering how the two binding elements cooperate. This product is therefore valuable for researchers optimizing linker architecture to improve the performance of targeted degradation agents in biochemical and cellular assays.
Structure of 658858-65-2
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THP-PEG8-alcohol is a polyethylene glycol (PEG)-based linker designed for modular synthesis of PROTACs, enabling efficient spatial spacing and improved solubility in aqueous and mixed organic systems. Its ether-rich chain and terminal alcohol functionality support reliable conjugation strategies to assemble ligand–linker–ligand architectures for targeted protein degradation. The detailed structural and reactivity considerations for constructing PROTACs using this linker are provided below.
Structure: The linker comprises a tetrahydropyran (THP) motif connected to a PEG chain and terminated with a primary alcohol. It contains multiple ether linkages that confer flexibility, polarity, and hydrogen-bonding capacity, supporting favorable conformational behavior in PROTAC constructs.
Reactivity: The terminal alcohol enables formation of PROTAC-ready intermediates via standard derivatization routes such as esterification or etherification, typically using activated carboxylic acid derivatives or halides under base catalysis. THP groups are commonly handled as protecting groups that can be removed under acidic conditions when required for downstream coupling. Solvents such as DMF, DMSO, or dichloromethane are frequently used to promote coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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