Tos-PEG13-Boc
Cat No.: BP-501732
4.5 
Tos-PEG13-Boc is a heterobifunctional PEG-based linker featuring a tosyl (tosylate) leaving group for nucleophilic substitution and a Boc-protected functional handle for controlled downstream derivatization. The structure comprises a linear, hydrophilic polyethylene glycol chain of intermediate length that provides conformational flexibility, reduces steric hindrance, and improves aqueous solubility of conjugates. In PROTAC architectures, such linkers are used to connect a ligand-bearing reactive group to an amine or other nucleophile on the partner module, enabling efficient formation of a stable conjugate without disrupting the binding pharmacophores. The PEG spacer can also influence effective molarity and the relative positioning of the two recruited proteins, which is critical for productive ternary complex formation. This product is therefore valuable for researchers optimizing targeted protein degradation constructs, where robust, modular synthesis and reliable linker behavior are required to compare degradation potency across series.
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* For research and manufacturing use only. Not for human or clinical use.
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Popular Publications Citing BOC Sciences Products
Tos-PEG13-Boc is a PEG-based bifunctional linker designed for modular assembly of PROTACs, enabling efficient conjugation between a ligand and an E3-recruiting or target-binding module. Its polyethylene glycol segment supports favorable solubility and conformational flexibility, while the protected functional group provides controlled reactivity during synthesis. The linker is particularly useful when sequential coupling and deprotection steps are required to build well-defined degraders. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a polyethylene glycol chain bearing a tosyl-derived leaving group at one end and a tert-butyl ester-protected carboxyl group at the other. Its structure includes repeating C–O ether linkages that impart hydrophilicity and flexibility, alongside a tert-butyl ester-protected carboxyl group that can be selectively cleaved under acid-mediated deprotection conditions.
Reactivity: Tos-PEG13-Boc is commonly used in PROTAC synthesis as a protected intermediate for stepwise functionalization. The tosyl-derived handle supports substitution-type coupling strategies, while the tert-butyl ester can be cleaved under acid-mediated conditions to reveal a carboxylic acid for subsequent activation and coupling. Typical workflows employ mild base or acid deprotection, with polar aprotic solvents and coupling reagents selected to match the exposed functional group’s chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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