Tr-PEG4-OH
CAS No.: 125274-16-0
Cat No.: BP-501262
Purity: ≥95%
4.5 
Tr-PEG4-OH is a heterobifunctional, terminally hydroxylated polyethylene glycol linker designed for PROTAC and related targeted protein degradation constructs. Structurally, it comprises a PEG4 chain that provides a flexible, hydrophilic spacer between two conjugation points, with the “Tr” handle enabling attachment to a partner ligand or reactive group while the terminal alcohol supports further derivatization (e.g., esterification or ether formation) under standard coupling conditions. In PROTAC design, PEG-based linkers are widely used to tune the effective distance and relative orientation between the target-binding moiety and the E3 ligase-recruiting ligand, thereby improving formation of the ternary complex and reducing steric clashes. This product’s short, well-defined PEG length is particularly useful when optimizing activity while maintaining favorable solubility and minimizing nonproductive aggregation. It is therefore valuable for systematic linker-scanning experiments and for constructing degraders where controlled flexibility and modular conjugation are required.
Structure of 125274-16-0
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Tr-PEG4-OH is a polyethylene glycol-based PROTAC linker building block designed to support targeted protein degradation workflows by improving solubility, tuning linker flexibility, and enabling robust conjugation chemistry between a ligand and an E3-recruiting module. Its PEG architecture is widely used in PROTAC designs to reduce aggregation and facilitate productive ternary complex formation. The structure and reactivity aspects of this linker are described in detail below.
Structure: Tr-PEG4-OH is a PEG-derived monofunctional linker featuring ether-rich repeating units that provide conformational flexibility. The terminal hydroxyl group enables further derivatization, while the ether oxygen atoms contribute to polarity and hydrogen-bonding capacity, supporting favorable aqueous compatibility.
Reactivity: The terminal hydroxyl group is suitable for standard PROTAC linker functionalization via hydroxyl-derivatization strategies, such as conversion to activated carbonates or ester-linked intermediates, followed by coupling to complementary nucleophiles on protein-binding ligands. Reactions are typically conducted under anhydrous, inert conditions with appropriate base and coupling reagents, using polar aprotic solvents to maintain PEG solubility and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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