PROTAC Library

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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
4-((17-(4-(((1-(6-Amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)-3,6,9,12,15-pentaoxaheptadecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-201673 4-((17-(4-(((1-(6-Amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)-3,6,9,12,15-pentaoxaheptadecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2624181-70-8

CRBN

SHP2

Inquiry

Molecular Weight: 952.88

Molecular Formula: C44H55Cl2N11O9

Density: 1.47±0.1 g/cm3

Description: It is a CRBN-recruiting PROTAC molecule targeting SHP2 by connecting pomalidomide with SHP099, an allosteric inhibitor of SHP2.

4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)acetamido)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide BPL-201674 4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)acetamido)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide 2648294-70-4

CRBN

HDAC1
HDAC2
HDAC3
HDAC6

Inquiry

Molecular Weight: 738.75

Molecular Formula: C35H42N6O12

Density: 1.384±0.06 g/cm3

Description: It is a proteolysis-targeting chimera (PROTAC), which efficiently degrades histone deacetylases.

HD-TAC1 BPL-201675 HD-TAC1

CRBN

HDAC3

Inquiry

Molecular Weight: 639.67

Molecular Formula: C33H33N7O7

Description: It is a proteolysis targeting chimera (PROTAC) that induces protein degradation of histone deacetylase 3 (HDAC3).

HD-TAC2 BPL-201676 HD-TAC2

CRBN

HDAC3

Inquiry

Molecular Weight: 582.62

Molecular Formula: C31H30N6O6

Description: It is a proteolysis targeting chimera (PROTAC) that induces protein degradation of histone deacetylase 3 (HDAC3).

HD-TAC3 BPL-201677 HD-TAC3

CRBN

HDAC2

Inquiry

Molecular Weight: 596.64

Molecular Formula: C32H32N6O6

Description: It is a proteolysis targeting chimera (PROTAC) that induces protein degradation of histone deacetylase 3 (HDAC3).

HD-TAC4 BPL-201678 HD-TAC4

CRBN

HDAC3

Inquiry

Molecular Weight: 568.59

Molecular Formula: C30H28N6O6

Description: It is a proteolysis targeting chimera (PROTAC) that induces protein degradation of histone deacetylase 3 (HDAC3).

HD-TAC5 BPL-201679 HD-TAC5

CRBN

HDAC2
HDAC3

Inquiry

Molecular Weight: 653.70

Molecular Formula: C34H35N7O7

Description: It is a proteolysis targeting chimera (PROTAC) that induces protein degradation of histone deacetylase 2 and 3 (HDAC2 and HDAC3).

HD-TAC6 BPL-201680 HD-TAC6

CRBN

HDAC3

Inquiry

Molecular Weight: 625.64

Molecular Formula: C32H31N7O7

Description: It is a proteolysis targeting chimera (PROTAC) that induces protein degradation of histone deacetylase 3 (HDAC3).

HD-TAC7 BPL-201681 HD-TAC7

CRBN

HDAC3

Inquiry

Molecular Weight: 657.66

Molecular Formula: C33H32FN7O7

Description: It is a proteolysis targeting chimera (PROTAC) that induces protein degradation of histone deacetylase 3 (HDAC3).

A001 BPL-201682 A001 2756586-39-5

CRBN

AR

Inquiry

Molecular Weight: 849.43

Molecular Formula: C47H53ClN6O7

Boiling Point: 996.5±65.0°C at 760 Torr

Density: 1.37±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A002 BPL-201683 A002 2756586-40-8

CRBN

AR

Inquiry

Molecular Weight: 848.45

Molecular Formula: C47H54ClN7O6

Boiling Point: 1013.8±65.0°C at 760 Torr

Density: 1.37±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A003 BPL-201684 A003 2756586-41-9

CRBN

AR

Inquiry

Molecular Weight: 834.42

Molecular Formula: C46H52ClN7O6

Boiling Point: 1009.9±65.0°C at 760 Torr

Density: 1.38±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A004 BPL-201685 A004 2756586-42-0

CRBN

AR

Inquiry

Molecular Weight: 820.39

Molecular Formula: C45H50ClN7O6

Boiling Point: 1005.6±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A005 BPL-201686 A005 2756586-43-1

CRBN

AR

Inquiry

Molecular Weight: 780.29

Molecular Formula: C40H42ClN9O6

Density: 1.49±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A006 BPL-201687 A006 2756586-44-2

CRBN

AR

Inquiry

Molecular Weight: 766.26

Molecular Formula: C39H40ClN9O6

Density: 1.51±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A007 BPL-201688 A007 2756586-45-3

CRBN

AR

Inquiry

Molecular Weight: 794.31

Molecular Formula: C41H44ClN9O6

Density: 1.47±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A008 BPL-201689 A008 2756586-46-4

CRBN

AR

Inquiry

Molecular Weight: 808.34

Molecular Formula: C42H46ClN9O6

Density: 1.45±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A009 BPL-201690 A009 2756586-47-5

CRBN

AR

Inquiry

Molecular Weight: 822.37

Molecular Formula: C43H48ClN9O6

Density: 1.43±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A010 BPL-201691 A010 2756586-48-6

CRBN

AR

Inquiry

Molecular Weight: 808.34

Molecular Formula: C42H46ClN9O6

Density: 1.45±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

A011 BPL-201692 A011 2756586-49-7

CRBN

AR

Inquiry

Molecular Weight: 794.31

Molecular Formula: C41H44ClN9O6

Density: 1.47±0.1 g/cm3

Description: It is an effective proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader for the treatment of prostate cancer.

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