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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
(2S,4R)-1-((S)-12-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,10-dioxo-3-oxa-2,7,11-triazatridecan-13-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201573 (2S,4R)-1-((S)-12-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,10-dioxo-3-oxa-2,7,11-triazatridecan-13-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-90-2

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 949.84

Molecular Formula: C41H47F3IN7O6S

Density: 1.472±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-13-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,11-dioxo-3-oxa-2,7,12-triazatetradecan-14-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201574 (2S,4R)-1-((S)-13-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,11-dioxo-3-oxa-2,7,12-triazatetradecan-14-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-92-4

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 963.86

Molecular Formula: C42H49F3IN7O6S

Density: 1.456±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-14-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,12-dioxo-3-oxa-2,7,13-triazapentadecan-15-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201575 (2S,4R)-1-((S)-14-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,12-dioxo-3-oxa-2,7,13-triazapentadecan-15-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-91-3

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 977.89

Molecular Formula: C43H51F3IN7O6S

Density: 1.441±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,13-dioxo-3-oxa-2,7,14-triazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201576 (2S,4R)-1-((S)-15-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,13-dioxo-3-oxa-2,7,14-triazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-93-5

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 991.92

Molecular Formula: C44H53F3IN7O6S

Density: 1.427±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-17-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,15-dioxo-3-oxa-2,7,16-triazaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201577 (2S,4R)-1-((S)-17-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,15-dioxo-3-oxa-2,7,16-triazaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-95-7

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1019.97

Molecular Formula: C46H57F3IN7O6S

Density: 1.401±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-18-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,16-dioxo-3-oxa-2,7,17-triazanonadecan-19-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201578 (2S,4R)-1-((S)-18-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,16-dioxo-3-oxa-2,7,17-triazanonadecan-19-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-94-6

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1033.98

Molecular Formula: C47H59F3IN7O6S

Density: 1.389±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-19-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,17-dioxo-3-oxa-2,7,18-triazaicosan-20-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201579 (2S,4R)-1-((S)-19-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,17-dioxo-3-oxa-2,7,18-triazaicosan-20-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-97-9

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1048.02

Molecular Formula: C48H61F3IN7O6S

Density: 1.377±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-14-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,12-dioxo-3,10-dioxa-2,7,13-triazapentadecan-15-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201580 (2S,4R)-1-((S)-14-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,12-dioxo-3,10-dioxa-2,7,13-triazapentadecan-15-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-86-6

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 979.86

Molecular Formula: C42H49F3IN7O7S

Density: 1.466±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,13-dioxo-3,10-dioxa-2,7,14-triazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201581 (2S,4R)-1-((S)-15-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,13-dioxo-3,10-dioxa-2,7,14-triazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-87-7

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 993.89

Molecular Formula: C43H51F3IN7O7S

Density: 1.451±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-17-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,15-dioxo-3,10,13-trioxa-2,7,16-triazaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201582 (2S,4R)-1-((S)-17-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,15-dioxo-3,10,13-trioxa-2,7,16-triazaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-96-8

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1023.91

Molecular Formula: C44H53F3IN7O8S

Density: 1.447±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-18-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,16-dioxo-3,10,13-trioxa-2,7,17-triazanonadecan-19-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201583 (2S,4R)-1-((S)-18-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,16-dioxo-3,10,13-trioxa-2,7,17-triazanonadecan-19-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-88-8

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1037.94

Molecular Formula: C45H55F3IN7O8S

Density: 1.433±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-21-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,19-dioxo-3,10,13,16-tetraoxa-2,7,20-triazadocosan-22-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201584 (2S,4R)-1-((S)-21-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,19-dioxo-3,10,13,16-tetraoxa-2,7,20-triazadocosan-22-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-98-0

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1081.99

Molecular Formula: C47H59F3IN7O9S

Density: 1.417±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-24-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,22-dioxo-3,10,13,16,19-pentaoxa-2,7,23-triazapentacosan-25-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201585 (2S,4R)-1-((S)-24-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,22-dioxo-3,10,13,16,19-pentaoxa-2,7,23-triazapentacosan-25-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2756322-99-1

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1126.05

Molecular Formula: C49H63F3IN7O10S

Density: 1.402±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-19-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,17-dioxo-3-oxa-2,7,18-triazaicosan-20-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201586 (2S,4R)-1-((S)-19-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,17-dioxo-3-oxa-2,7,18-triazaicosan-20-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2756323-14-3

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1062.05

Molecular Formula: C49H63F3IN7O6S

Density: 1.365±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-21-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,19-dioxo-3-oxa-2,7,20-triazadocosan-22-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201587 (2S,4R)-1-((S)-21-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,19-dioxo-3-oxa-2,7,20-triazadocosan-22-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2756323-12-1

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1090.09

Molecular Formula: C51H67F3IN7O6S

Density: 1.344±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
MS928 BPL-201588 MS928 2756323-64-3

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1090.09

Molecular Formula: C51H67F3IN7O6S

Density: 1.346±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-20-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,18-dioxo-3-oxa-2,8,19-triazahenicosan-21-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201589 (2S,4R)-1-((S)-20-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,18-dioxo-3-oxa-2,8,19-triazahenicosan-21-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2756323-13-2

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1076.08

Molecular Formula: C50H65F3IN7O6S

Density: 1.354±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
(2S,4R)-1-((S)-21-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,19-dioxo-3-oxa-2,8,20-triazadocosan-22-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-201590 (2S,4R)-1-((S)-21-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,19-dioxo-3-oxa-2,8,20-triazadocosan-22-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2756323-16-5

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1090.09

Molecular Formula: C51H67F3IN7O6S

Density: 1.344±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
MS934 BPL-201591 MS934 2756323-15-4

VHL

MEK1
MEK2

 Inquiry

Molecular Weight: 1104.13

Molecular Formula: C52H69F3IN7O6S

Density: 1.334±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.
N-(3-((3-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)amino)propoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide BPL-201592 N-(3-((3-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)amino)propoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 2756323-05-2

CRBN

MEK1
MEK2

 Inquiry

Molecular Weight: 778.53

Molecular Formula: C32H30F3IN6O6

Density: 1.641±0.06 g/cm3

Description: It is a potent and selective mitogen-activated protein kinase kinase 1/2 (MEK1/2) heterobifunctional small-molecule degrader.

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