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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
(2S,4R)-1-((S)-2-(tert-Butyl)-17-(4-((2-(3-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200813 (2S,4R)-1-((S)-2-(tert-Butyl)-17-(4-((2-(3-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462002-00-0

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Molecular Weight: 1141.38

Molecular Formula: C61H68N6O12S2

Density: 1.32±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-1-((S)-2-(tert-Butyl)-20-(4-((2-(3-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200814 (2S,4R)-1-((S)-2-(tert-Butyl)-20-(4-((2-(3-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462002-51-1

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Molecular Weight: 1185.43

Molecular Formula: C63H72N6O13S2

Density: 1.32±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-1-((S)-2-(tert-Butyl)-23-(4-((2-(3-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200815 (2S,4R)-1-((S)-2-(tert-Butyl)-23-(4-((2-(3-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462002-98-6

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Molecular Weight: 1229.48

Molecular Formula: C65H76N6O14S2

Density: 1.31±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200816 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462003-45-6

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Molecular Weight: 981.17

Molecular Formula: C53H52N6O9S2

Density: 1.37±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200817 (2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462004-04-0

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Molecular Weight: 1009.22

Molecular Formula: C55H56N6O9S2

Density: 1.35±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200818 (2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462004-46-0

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Molecular Weight: 1023.25

Molecular Formula: C56H58N6O9S2

Density: 1.34±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200819 (2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462005-18-9

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Molecular Weight: 1037.27

Molecular Formula: C57H60N6O9S2

Density: 1.33±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200820 (2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462005-72-5

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 Inquiry

Molecular Weight: 1051.30

Molecular Formula: C58H62N6O9S2

Density: 1.32±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(8-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)octanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200821 (2S,4R)-4-Hydroxy-1-((S)-2-(8-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)octanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462006-30-8

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 Inquiry

Molecular Weight: 1065.33

Molecular Formula: C59H64N6O9S2

Density: 1.31±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200822 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462006-85-3

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 Inquiry

Molecular Weight: 1025.22

Molecular Formula: C55H56N6O10S2

Density: 1.36±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200823 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(2-(2-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462007-41-4

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 Inquiry

Molecular Weight: 1069.27

Molecular Formula: C57H60N6O11S2

Density: 1.35±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200824 (2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462007-81-2

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 Inquiry

Molecular Weight: 1113.32

Molecular Formula: C59H64N6O12S2

Density: 1.34±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-1-((S)-2-(tert-Butyl)-17-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200825 (2S,4R)-1-((S)-2-(tert-Butyl)-17-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462008-33-7

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 Inquiry

Molecular Weight: 1157.38

Molecular Formula: C61H68N6O13S2

Density: 1.33±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-1-((S)-2-(tert-Butyl)-20-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200826 (2S,4R)-1-((S)-2-(tert-Butyl)-20-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462009-12-5

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 Inquiry

Molecular Weight: 1201.43

Molecular Formula: C63H72N6O14S2

Density: 1.32±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-1-((S)-2-(tert-Butyl)-23-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200827 (2S,4R)-1-((S)-2-(tert-Butyl)-23-(4-((2-(3-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)benzoyl)hydrazineylidene)methyl)phenoxy)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462009-64-7

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ER

 Inquiry

Molecular Weight: 1245.48

Molecular Formula: C65H76N6O15S2

Density: 1.32±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200828 (2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462010-13-3

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 Inquiry

Molecular Weight: 889.07

Molecular Formula: C47H48N6O8S2

Density: 1.39±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200829 (2S,4R)-4-Hydroxy-1-((S)-2-(4-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462010-67-7

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 Inquiry

Molecular Weight: 917.12

Molecular Formula: C49H52N6O8S2

Density: 1.36±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200830 (2S,4R)-4-Hydroxy-1-((S)-2-(5-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462011-47-6

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Molecular Weight: 931.15

Molecular Formula: C50H54N6O8S2

Density: 1.35±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200831 (2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)hexanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462012-15-1

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Molecular Weight: 945.18

Molecular Formula: C51H56N6O8S2

Density: 1.34±0.1 g/cm3

Description: It is a potent ER degrader.
(2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide BPL-200832 (2S,4R)-4-Hydroxy-1-((S)-2-(7-(4-((2-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)hydrazineylidene)methyl)phenoxy)heptanamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 2462012-68-4

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Molecular Weight: 959.20

Molecular Formula: C52H58N6O8S2

Density: 1.33±0.1 g/cm3

Description: It is a potent ER degrader.

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