Warhead Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	Molecular Formula	Molecular Weight	Target	Inquiry
	BPL-100064	5-(4-fluoro-3-methylphenyl)-4-[4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl]pyrimidine	335063-33-7	C20H22FN5	351.42	SLC9A1	Inquiry
	BPL-100065	BMS-8	1675201-90-7	C27H28BrNO3	494.42	PD-L1	Inquiry
Description: BMS-8 inhibits the PD-1/PD-L1 interaction with IC50 of 7.2 μM.
	BPL-100066	IACS-7e	1800477-13-7	C26H29N3O7S	527.59	TRIM24	Inquiry
Description: IACS-7e is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM.
	BPL-100067	AP1867	195514-23-9	C38H47NO11	693.78	FKBP12 F36V	Inquiry
Description: AP1867 is a precursor for the dTAG system which pairs a novel degrader of FKBP12(F36V) with expression of FKBP12(F36V) in-frame with a protein of interest.
	BPL-100068	Flortaucipir F 18	1522051-90-6	C16H10FN3	262.27	Tau	Inquiry
	BPL-100069	RA190	2375455-60-8	C28H22Cl4N2O2	560.30	Rpn13	Inquiry
Description: RA190 is a bis-benzylidine piperidon that inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
	BPL-100070	N2-(4-methoxyphenyl)-N4-(quinolin-3-yl)pyrimidine-2,4-diamine	500543-88-4	C20H17N5O	343.38	IGF-1R	Inquiry
	BPL-100071	RBx10080307	1453118-79-0	C20H23FN8	394.45	IGF-1R	Inquiry
	BPL-100072	(2S,4S)-4-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-prop-2-enoylpyrrolidine-2-carboxylic acid	2561412-36-8	C25H22N6O4	470.48	BTK	Inquiry
	BPL-100073	(4S)-5-[3-[[5-[[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]benzoyl]amino]pyrimidin-2-yl]amino]anilino]-5-oxo-4-(prop-2-enoylamino)pentanoic acid	2044974-88-9	C34H30F3N7O6	689.64	BTK	Inquiry
	BPL-100074	(2S,4S)-4-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-propanoylpyrrolidine-2-carboxylic acid	2561415-68-5	C25H24N6O4	472.51	BTK	Inquiry
	BPL-100075	(4S)-5-[3-[[5-[[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]benzoyl]amino]pyrimidin-2-yl]amino]anilino]-5-oxo-4-(propanoylamino)pentanoic acid	2561412-41-5	C34H32F3N7O6	691.66	BTK	Inquiry
	BPL-100076	JH-VIII-49	2209084-73-9	C30H40N2	428.66	CDK8	Inquiry
Description: JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM. It also inhibits CDK19 (IC50=8 nM).
	BPL-100077	Ibrutinib	936563-96-1	C25H24N6O2	440.50	ABL2 BLK BTK CSK FYN LCK Src TEC	Inquiry
Description: Ibrutinib is a potent and selective BTK inhibitor (IC50=0.5 nM).
	BPL-100078	N-[6-(hydroxymethyl)-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide	509093-90-7	C23H24F3N3O3	447.45	IRAK4	Inquiry
	BPL-100079	JBJ-07-149	2140807-58-3	C28H26N6O2S	510.61	EGFR	Inquiry
	BPL-100080	N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-3-chloropropanamide	1801692-35-2	C16H21ClN6S	364.90	SHP2	Inquiry
	BPL-100081	4-[4-(4-hydroxyphenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile	959690-10-9	C19H14F3N3O3	389.32	AR	Inquiry
	BPL-100082	N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-3-(4-hydroxyphenoxy)-2-methylpropanamide	2540587-05-9	C18H15F3N2O4	380.31	AR	Inquiry
	BPL-100083	(3E)-1-benzyl-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	1802322-84-4	C24H18N2O3	382.41	Alpha-syn	Inquiry