Warhead Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	Molecular Formula	Molecular Weight	Target	Inquiry
	BPL-100102	SR-3558	1816294-65-1	C17H20N2O	268.35	HDAC1 HDAC2 HDAC3	Inquiry
	BPL-100103	6-(5-cyanopyrrolo[2,3-b]pyridin-1-yl)-N-[4-(cyclopropylcarbamoyl)cyclohexyl]-4-(propan-2-ylamino)pyridine-3-carboxamide	1800553-60-9	C27H31N7O2	485.59	IRAK4	Inquiry
	BPL-100104	3-Methylthienyl-carbonyl-JNJ-7706621	443798-09-2	C14H14N6O3S2	378.43	CDK2	Inquiry
Description: 3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective cyclin-dependent kinase (CDK) inhibitor, with IC50s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. It also has strong inhibitory effect on GSK-3 (IC50 = 0.041 μM) and modest potency against CDK4, VEGF-R2 and FGF-R2 with IC50s of 0.11, 0.13 and 0.22 μM, respectively. It can be used in cancer research.
	BPL-100105	2-(4-piperazin-1-ylanilino)-5,7-dihydropyrimido[5,4-d][1,3]benzodiazepin-6-one	1628613-51-3	C21H21N7O	387.44	ABL2 EPHB2 SIK2 TYK2	Inquiry
	BPL-100106	4-[6-amino-5-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)pyridin-3-yl]-N-cyclopropyl-3-fluorobenzenesulfonamide		C23H21FN4O3S	452.50	CDK14 CSNK1A1 CSNK1D CSNK1E GSK3A GSK-3beta LIMK2 MAP3K1 MINK1 NUAK1 PAK4 PIM2 STK10 STK17B STK35 STK4	Inquiry
	BPL-100107	N-hydroxy-3-methylbenzamide	10335-81-6	C8H9NO2	151.16	HDAC6 HDAC8	Inquiry
	BPL-100108	3-N-hydroxy-1-N-methylbenzene-1,3-dicarboxamide	1440210-04-7	C9H10N2O3	194.19	HDAC6 HDAC8	Inquiry
	BPL-100109	5-chloro-2-N-[(3R)-piperidin-3-yl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	2519822-93-4	C18H24ClN5O2S	409.93	CDK12	Inquiry
	BPL-100110	6-(tert-butylsulfonyl)-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-methoxyquinazolin-4-amine	1423187-07-8	C18H23N5O3S	389.47	RIPK2	Inquiry
	BPL-100111	LDC59	1453833-35-6	C24H30N8O	446.56	CDK9	Inquiry
	BPL-100112	LDC3140	1453833-30-1	C23H33N7O	423.57	CDK9	Inquiry
Description: LDC3140 is a potent and selective CDK7 inhibitor.
	BPL-100113	N-benzyl-2-(1-methylpiperidin-4-yl)oxy-8-propan-2-ylpyrazolo[1,5-a][1,3,5]triazin-4-amine	1453836-45-7	C21H28N6O	380.50	CDK9	Inquiry
	BPL-100114	N-[(1S,3S)-3-(3-chloro-4-cyanophenoxy)cyclopentyl]benzamide		C19H17ClN2O2	340.81	AR	Inquiry
	BPL-100115	N-[(1R,4R)-4-(3-chloro-4-cyanophenoxy)cycloheptyl]benzamide		C21H21ClN2O2	368.86	AR	Inquiry
	BPL-100116	N-[5-(3-chloro-4-cyanophenoxy)cyclooctyl]benzamide		C22H23ClN2O2	382.89	AR	Inquiry
	BPL-100117	4-(1-benzoylazepan-4-yl)oxy-2-chlorobenzonitrile		C20H19ClN2O2	354.83	AR	Inquiry
	BPL-100118	N-[4-(3-chloro-4-cyanoanilino)cyclohexyl]benzamide	2830637-07-3	C20H20ClN3O	353.85	AR	Inquiry
	BPL-100119	N-[4-(3-chloro-4-cyano-N-methylanilino)cyclohexyl]benzamide	2830637-08-4	C21H22ClN3O	367.88	AR	Inquiry
	BPL-100120	N-[4-(3-chloro-4-cyano-N-ethylanilino)cyclohexyl]benzamide	2830637-09-5	C22H24ClN3O	381.90	AR	Inquiry
	BPL-100121	N-[4-(3-chloro-4-cyano-N-propylanilino)cyclohexyl]benzamide		C23H26ClN3O	395.90	AR	Inquiry