3,6,9,12-Tetraoxatetradecane-1,14-diyl diacrylate

3,6,9,12-Tetraoxatetradecane-1,14-diyl diacrylate, is an acrylate-terminated, poly(ethylene glycol)-like tether designed to connect a ligand for an E3 ligase to a target-binding moiety. Its flexible ether-rich backbone supports productive ternary complex formation, while the diacrylate handles enable modular conjugation under standard polymer/bioconjugation chemistries. The following sections describe its structure and practical reactivity considerations for constructing degraders.

Structure: The linker contains an ether-rich, tetraoxatetradecane backbone providing conformational flexibility, terminated by two acrylate groups. It features ester linkages and vinyl unsaturation suitable for Michael-type or radical addition chemistry, with an overall hydrophilic character that can improve solubility and reduce nonspecific interactions.

Reactivity: The acrylate termini can be used for conjugation to nucleophilic functional groups via Michael addition or related addition mechanisms, commonly under mild base or nucleophile activation depending on the partner chemistry. For acrylate-based coupling, appropriate solvents such as polar aprotic or aqueous co-solvent systems are typically selected to balance solubility and reaction rate. Reaction conditions should be optimized to preserve sensitive ligands and to minimize acrylate polymerization; radical initiators or inhibitors may be considered when using addition pathways that involve radical character.