MS4078

 CAS No.: 2229036-62-6  Cat No.: BP-400056 4.5  

MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM); induces ALK protein degradation via cereblon and proteasome dependent mechanism, potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.

MS4078

Structure of 2229036-62-6

Quality
Assurance

Worldwide
Delivery

24/7 Customer
Support
Category
PROTAC
Molecular Formula
C45H52ClN9O8S
Molecular Weight
914.47

* For research and manufacturing use only. Not for human or clinical use.

SizePriceStockQuantity
-- $-- In stock

Looking for different specifications? Click to request a custom quote!

Capabilities & Facilities

  • mg to g scale for early stage;
  • CDMO and CMO support.
  • 24/7 customer service;
  • 100% quality assurance;
  • Efficient global delivery;
  • Over 95% customer satisfaction.
Popular Publications Citing BOC Sciences Products
Solubility
10 mM in DMSO
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere
Synonyms
MS-4078; MS4078; MS 4078; 2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]-N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]acetamide
InChI Key
AYMGZLUKTNXEMY-UHFFFAOYSA-N
InChI
InChI=1S/C45H52ClN9O8S/c1-25(2)63-36-22-30(27(5)21-34(36)51-45-49-23-31(46)41(53-45)50-32-10-6-7-12-37(32)64(61,62)26(3)4)28-15-19-54(20-16-28)24-39(57)48-18-17-47-33-11-8-9-29-40(33)44(60)55(43(29)59)35-13-14-38(56)52-42(35)58/h6-12,21-23,25-26,28,35,47H,13-20,24H2,1-5H3,(H,48,57)(H,52,56,58)(H2,49,50,51,53)
Canonical SMILES
CC1=CC(=C(C=C1C2CCN(CC2)CC(=O)NCCNC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O)OC(C)C)NC6=NC=C(C(=N6)NC7=CC=CC=C7S(=O)(=O)C(C)C)Cl

Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

Calculate
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g
Historical Records: SHP2-D26 | TD-165

Related Product Recommendations

In Stock Purity: ≥98% (HPLC) Hot
Lenalidomide
Lenalidomide

CAS: 191732-72-6
In Stock Purity: ≥95% Hot
Afimoxifene
Afimoxifene

CAS: 68392-35-8
In Stock Purity: ≥95% Hot
Propargyl-PEG5-acid
Propargyl-PEG5-acid

CAS: 1245823-51-1
In Stock Purity: >98% Hot
DCC-2618
DCC-2618

CAS: 1225278-16-9
In Stock Hot
Ribociclib
Ribociclib

CAS: 1211441-98-3
In Stock Purity: >98% Hot
Idasanutlin
Idasanutlin

CAS: 1229705-06-9
BOC Sciences Support

Please contact us with any specific requirements and we will get back to you as soon as possible.


  • Verification code

We invite you to contact us at or through our contact form above for more information about our services and products.

USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
Germany
Copyright © 2025 BOC Sciences. All Rights Reserved.
Inquiry Basket
Loading......
Delete selected Go to checkout