AcS-PEG6-t-butyl ester
CAS No.: 1818294-39-1
Cat No.: BP-501607
Purity: ≥95%
4.5 
AcS-PEG6-t-butyl ester is a PEG-based PROTAC linker featuring an acetylthio (AcS) thioether handle and a terminal tert-butyl ester that can serve as a protected carboxyl functionality. Structurally, it provides a flexible, water-compatible poly(ethylene glycol) chain of moderate length, which helps to spatially separate the two binding elements of a PROTAC and reduce steric interference during ternary complex formation. The AcS thioether moiety is suitable for downstream conjugation or exchange reactions that install the linker onto a targeting ligand or a recruiter scaffold, while the tert-butyl ester can be deprotected under standard laboratory conditions to reveal a reactive carboxyl group for amide coupling. In targeted protein degradation research, such linkers are valuable for tuning linker length and polarity, improving solubility, and enabling systematic optimization of degradation potency and selectivity by facilitating productive engagement of the E3 ligase and the target protein.
Structure of 1818294-39-1
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AcS-PEG6-t-butyl ester is a PEG-based PROTAC linker designed to provide a hydrophilic, conformationally flexible spacer between a target-binding ligand and an E3 ligase-recruiting moiety. Its ester functionality enables controlled downstream derivatization to generate reactive intermediates for conjugation workflows commonly used in targeted protein degradation. The PEG segment can improve solubility and reduce nonspecific interactions, facilitating efficient assembly of degraders. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains an ethylene glycol–rich PEG chain and a tert-butyl ester group, incorporating an ester linkage and ether-like repeating units. The presence of an alkyl ester provides a protected carboxyl equivalent, while the PEG segment offers hydrophilic character and flexible conformational behavior.
Reactivity: The tert-butyl ester is typically cleaved under acidic conditions to reveal a carboxylic acid for subsequent amide or ester-forming coupling. For PROTAC construction, the liberated acid can be activated using standard carboxyl-activation chemistries (e.g., carbodiimide-based systems) in polar aprotic solvents, followed by nucleophilic substitution with an appropriate amine-bearing ligand. Mechanistically, acid-promoted deprotection proceeds via ester cleavage to generate the reactive acid intermediate.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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