HO-PEG12-COOMe
CAS No.: 1239588-11-4
Cat No.: BP-500794
Purity: >97%
4.5 
HO-PEG12-COOMe is a methoxycarbonyl-terminated, hydroxyl-initiated polyethylene glycol linker designed for PROTAC and targeted protein degradation workflows. Structurally, it comprises a PEG chain of defined length bearing a terminal methyl ester, providing a flexible, hydrophilic spacer that can reduce steric interference between the ligand-binding modules of a PROTAC. In PROTAC architectures, such PEG linkers help position the E3 ligase ligand and the target-binding ligand in a geometry favorable for ternary complex formation, while the ether-rich backbone improves solubility and can modulate the effective distance and conformational freedom during binding. The methyl ester functionality serves as a chemically addressable handle for subsequent derivatization or conversion to more reactive carboxylate forms, enabling controlled conjugation strategies. This linker is valuable for constructing degraders where maintaining aqueous compatibility and tuning inter-ligand spacing are critical for optimizing degradation efficiency and experimental reproducibility.
Structure of 1239588-11-4
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This HO-PEG12-COOMe linker is a polyethylene glycol-based degraders’ scaffold designed to connect ligands in targeted protein degradation platforms. Its flexible, hydrophilic PEG character can help tune linker length and solubility, supporting effective formation of PROTAC conjugates and improving handling in aqueous workflows. The molecule will be described in detail below, including its structural features and practical considerations for PROTAC assembly.
Structure: The linker comprises a PEG ether backbone terminated by a hydroxyl group and a methyl ester, providing a flexible, water-compatible scaffold. It contains ether linkages along the chain and an ester functional group at the terminus, enabling controlled conjugation while maintaining conformational mobility.
Reactivity: The methyl ester and terminal hydroxyl enable common PROTAC linker transformations, including ester hydrolysis to the corresponding carboxylic acid followed by amide coupling to install ligand attachment sites. Suitable conditions typically involve aqueous or mixed solvents with base or acid for hydrolysis, then coupling reagents for amide bond formation. Protecting-group strategies and careful pH control are often used to preserve sensitive ligand functionalities.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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