HO-PEG3-COOMe
CAS No.: 2086688-97-1
Cat No.: BP-500459
Purity: ≥95%
4.5 
HO-PEG3-COOMe is a methoxycarbonyl-terminated, hydroxyl-capped polyethylene glycol linker in which a short three-unit PEG chain provides a flexible, hydrophilic spacer between PROTAC-relevant fragments. Structurally, it contains an ether-linked PEG backbone that can reduce steric congestion and improve solubility, while the terminal methyl ester offers a convenient functional handle for subsequent coupling or conversion to other reactive groups under standard synthetic conditions. In PROTAC design, such PEG linkers help position a ligand–recruiter conjugate so that the two binding moieties can engage their respective target and E3 ligase with sufficient spatial freedom, thereby supporting productive formation of the ternary complex. Its short PEG length is often used to tune linker reach without excessive lengthening that could weaken effective proximity. This product is valuable for constructing and optimizing targeted protein degradation probes, enabling systematic evaluation of linker effects on degradation potency, selectivity, and cellular performance.
Structure of 2086688-97-1
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HO-PEG3-COOMe is a polyethylene glycol–based linker building block designed for constructing PROTACs through reliable, modular conjugation chemistry. Its PEG segment supports solubility and conformational flexibility, which can help tune the spatial relationship between the target-binding ligand and the E3-recruiting moiety. The methyl ester functionality enables straightforward synthetic handling and subsequent functional conversion, facilitating efficient PROTAC assembly. Detailed structure and reactivity considerations are provided below.
Structure: The linker comprises a PEG chain terminated by a hydroxyl group and a methyl ester (carboxylate ester). It contains ether linkages along the PEG backbone, plus an ester carbonyl and methoxy substituent. The combination yields a polar, hydrogen-bonding-capable, flexible scaffold with favorable solvation behavior.
Reactivity: The methyl ester can undergo standard ester transformations under conditions commonly used for ester activation or hydrolysis, enabling conversion to carboxylic acid or coupling-ready derivatives for PROTAC synthesis. Typical routes include nucleophilic acyl substitution and subsequent amide or ester bond formation to attach ligands. Mild base or acid conditions, appropriate coupling reagents, and polar aprotic solvents are generally employed to preserve sensitive functional groups during conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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