Ald-Ph-amido-PEG24-acid
Cat No.: BP-501934
4.5 
Ald-Ph-amido-PEG24-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring an aldehyde (Ald) terminus, a phenyl amide connection, and a terminal carboxylic acid. The PEG chain provides a hydrophilic, flexible spacer that can reduce steric interference and improve the effective reach between the two conjugation partners in a PROTAC architecture, while the phenyl amide segment offers a defined attachment point for building block assembly. In targeted protein degradation workflows, the aldehyde group enables chemoselective conjugation to amine-containing ligands (for example, via Schiff base formation followed by stabilization), and the terminal acid allows coupling to carboxyl-reactive handles or activation strategies used to connect to the complementary binding moiety. This linker is particularly valuable for constructing degraders in which balanced linker length and rigidity are critical for enabling productive ternary complex formation between the target-binding ligand and the E3 ligase recruiter, thereby supporting systematic structure–activity optimization.
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* For research and manufacturing use only. Not for human or clinical use.
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Ald-Ph-amido-PEG24-acid is a PEG-based PROTAC linker designed to connect a ligand-bearing electrophile to an acid-functional handle, enabling modular assembly of targeted protein degraders. Its ether-rich, flexible scaffold supports productive ternary-complex formation by improving linker solubility and conformational adaptability. The aldehyde and amide/acid functionalities facilitate chemoselective conjugation strategies commonly used in PROTAC synthesis. The structure and reactivity considerations are described in detail below.
Structure: The linker comprises an extended poly(ethylene glycol) chain with ether linkages, providing high hydrophilicity and conformational flexibility. It contains an aldehyde group for electrophilic coupling, a phenyl-amide motif for stable amide formation, and a terminal carboxylic acid for further derivatization. These features support robust, water-compatible linker behavior.
Reactivity: The aldehyde can participate in nucleophile-driven conjugation, including formation of imines or related reversible adducts under mild conditions, which can be leveraged for controlled PROTAC assembly. The carboxylic acid is suitable for amide coupling using standard peptide-coupling chemistries, typically with activating reagents and base in polar aprotic solvents. The amide linkage formed is stable, supporting durable linker integrity during synthesis and downstream assays.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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