Amino-PEG13-amine
CAS No.: 1228119-65-0
Cat No.: BP-500160
4.5 
Amino-PEG13-amine is a bifunctional, linear polyethylene glycol linker bearing terminal primary amine groups, providing a flexible hydrophilic chain of approximately thirteen ethylene glycol units. Structurally, it offers two reactive handles that can be used to install the linker between a ligand-based targeting module and an E3 ligase–recruiting moiety, typically via amide coupling, reductive amination, or other amine-reactive conjugation chemistries compatible with PROTAC synthesis. In PROTAC designs, PEG linkers are widely used to tune the effective distance and relative orientation between binding domains, reduce steric constraints, and improve aqueous solubility, thereby facilitating productive ternary complex formation and degradation efficiency. This linker’s terminal amines enable straightforward modular assembly and late-stage functionalization, making it valuable for constructing and optimizing targeted protein degradation probes, including structure–activity relationship studies that assess how linker length and flexibility influence cellular activity.
Structure of 1228119-65-0
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| -- | $-- | In stock |
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| ConcentrationVolumeMass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.5803 mL | 7.9016 mL | 15.8033 mL |
| 5 mM | 0.3161 mL | 1.5803 mL | 3.1607 mL |
| 10 mM | 0.1580 mL | 0.7902 mL | 1.5803 mL |
This Amino-PEG13-amine linker is a polyethylene glycol (PEG) based bifunctional spacer designed for modular assembly of PROTACs and other targeted protein degradation constructs. Its flexible, hydrophilic backbone helps tune linker length and solvation, supporting efficient conjugation between ligand-bearing fragments. The terminal amines enable straightforward coupling strategies while maintaining chemical compatibility across common PROTAC synthesis workflows. Detailed structural and reactivity considerations are provided below.
Structure: Amino-PEG13-amine is a PEG chain terminated with primary amines, featuring repeating ether linkages that confer flexibility and strong hydrogen-bonding capacity. The molecule contains carbon–nitrogen and carbon–oxygen bonds, with an overall polar, water-compatible character typical of PEG-based linkers.
Reactivity: The primary amines are suitable for amide bond formation, reductive amination, or nucleophilic substitution steps used to connect PROTAC ligand fragments to a spacer. Coupling is commonly performed under standard peptide/amide coupling conditions using carbodiimide or activated ester approaches, often in polar aprotic solvents with base. Reaction success generally depends on maintaining amine reactivity while minimizing PEG chain side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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