Amino-PEG9-alcohol
CAS No.: 15332-95-3
Cat No.: BP-501202
Purity: ≥95%
4.5 
Amino-PEG9-alcohol is a heterobifunctional polyethylene glycol (PEG) linker bearing a terminal primary amine and a terminal hydroxyl group, providing a flexible, hydrophilic chain of intermediate length suitable for conjugation chemistry. In PROTAC and targeted protein degradation workflows, such bifunctional PEG linkers are used to spatially separate the ligand “warhead” (e.g., an E3 ligase binder) from the second binding moiety, helping to tune effective distance, reduce steric clashes, and improve productive ternary complex formation. The terminal amine can be employed for amide coupling or reductive amination to attach one component, while the hydroxyl end can serve as a handle for further derivatization (e.g., activation to enable ether/ester formation or other linker-extension strategies). This linker is valuable for systematically optimizing linker length and attachment geometry in degradation constructs, supporting reproducible synthesis and structure–activity relationship studies aimed at maximizing degradation potency and stability in experimental settings.
Structure of 15332-95-3
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Amino-PEG9-alcohol is a polyethylene glycol (PEG)-based linker featuring a terminal primary amine and a terminal alcohol, enabling versatile conjugation strategies for targeted protein degradation (PROTAC) workflows. Its flexible, hydrophilic scaffold can improve solubility and provide adaptable spatial presentation of binding motifs. The molecule is commonly used as a modular intermediate for assembling PROTACs, and its practical functional handles are described in detail below.
Structure: The linker contains a PEG ether backbone composed of repeating ethylene glycol units, terminating in a primary amine and a primary alcohol. It features multiple ether linkages, hydrogen-bonding heteroatoms, and flexible conformational freedom, typically yielding a hydrophilic, water-compatible linker suitable for bioconjugation.
Reactivity: The primary amine can be used for amide-bond formation (for example, via activated carboxylic acids or carboxylate coupling reagents) and for carbamate formation with activated carbonyl derivatives. The terminal alcohol can participate in esterification or ether-forming reactions using appropriate leaving-group activation. In PROTAC assembly, these transformations are generally performed under standard organic coupling conditions with dry, compatible solvents and bases to drive chemoselective functionalization.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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