Amino-PEG9-t-butyl ester
CAS No.: 1818294-44-8
Cat No.: BP-501163
Purity: >99%
4.5 
Amino-PEG9-t-butyl ester is a PEG-based linker building block featuring a terminal primary amine for bioconjugation and a protected carboxylate masked as a tert-butyl ester at the other end. The PEG chain provides a flexible, hydrophilic spacer that can reduce steric interference and improve the effective reach between a ligand-bearing moiety and the recruited E3 ligase-binding partner in PROTAC constructs. In targeted protein degradation designs, this linker is used to connect two functional domains through amide or related coupling chemistries after deprotection, enabling formation of a defined conjugate that can bring the target protein and ubiquitin ligase into proximity to support ubiquitination and subsequent proteasomal degradation. Its utility lies in offering a tunable, experimentally tractable distance and solubility profile, which can be critical for optimizing ternary complex formation, cellular uptake, and degradation potency across linker length and attachment-point variations.
Structure of 1818294-44-8
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Amino-PEG9-t-butyl ester is a PEG-based linker designed to support targeted protein degradation (PROTAC) workflows by providing a hydrophilic, conformationally flexible spacer and a protected carboxylate handle for stepwise bioconjugation. Its amino functionality enables reliable coupling to ligands or intermediate fragments, while the tert-butyl ester supports controlled deprotection strategies. The detailed structural and reactivity considerations for constructing PROTACs are provided below.
Structure: The linker contains a polyethylene glycol chain bearing a terminal amino group and a tert-butyl ester at the opposite end. It features ether linkages within the PEG backbone, an aliphatic tert-butyl ester moiety, and a primary amine suitable for amide or urea formation. Overall, it is typically water-compatible and conformationally flexible.
Reactivity: The amino terminus is commonly used for nucleophilic acyl substitution or coupling to activated carboxylic acids (for example, via carbodiimide-mediated amide bond formation) under standard peptide-coupling conditions. The tert-butyl ester is a protecting group that can be removed under acid-promoted conditions to reveal a carboxylic acid for subsequent coupling. Solvent systems are typically chosen to balance PEG solubility and coupling efficiency, with bases and coupling reagents selected to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
