Azido-PEG10-alcohol
CAS No.: 877239-09-3
Cat No.: BP-501382
Purity: >97%
4.5 
Azido-PEG10-alcohol is a heterobifunctional polyethylene glycol (PEG) linker bearing a terminal azide group and a hydroxyl group, providing a flexible, hydrophilic chain that can be used to tune solubility and spatial presentation in PROTAC constructs. The azide handle enables site-specific conjugation via copper-free click chemistry (strain-promoted azide–alkyne cycloaddition) or related azide-reactive coupling strategies to attach the linker to a targeting ligand or E3 ligase-binding moiety bearing a complementary cyclooctyne/alkyne functionality. The terminal alcohol can serve as a reactive site for further derivatization (e.g., esterification or ether formation) to introduce additional functional groups or to connect to other PROTAC components. In targeted protein degradation research, PEG-based linkers are widely used to reduce steric clashes, improve linker flexibility, and facilitate efficient formation of the ternary complex between the two binding partners. This product is therefore valuable for assembling modular, chemically defined PROTACs for systematic structure–activity studies.
Structure of 877239-09-3
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Azido-PEG10-alcohol is a PEG-based linker bearing a terminal azide handle, designed for efficient modular assembly of PROTACs via bioorthogonal “click” conjugation. Its flexible poly(ethylene glycol) segment can help tune linker length and conformational mobility, supporting productive ternary complex formation in targeted protein degradation workflows. The azide functionality enables reliable coupling to complementary alkyne-bearing ligands, and the alcohol terminus provides an additional site for derivatization. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a poly(ethylene glycol) chain terminated by an azide group and a primary alcohol. It contains ether linkages characteristic of PEG, along with an organic azide moiety and a hydroxyl group. The resulting amphiphilic, flexible framework supports solubility and reduced steric constraints during conjugation.
Reactivity: The terminal azide is suitable for copper-catalyzed azide–alkyne cycloaddition to form a stable triazole linkage, a widely used strategy in PROTAC synthesis. Typical approaches employ Cu(I) sources generated in situ, with appropriate ligands to control copper speciation, and polar solvents compatible with both reactants. Reaction conditions are selected to preserve sensitive functional groups on protein-binding ligands while maximizing click efficiency and minimizing side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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