Azido-PEG12-Boc
Cat No.: BP-501908
4.5 
Azido-PEG12-Boc is a polyethylene glycol–based PROTAC linker featuring an azide functional group for bioorthogonal conjugation and a tert-butyl ester-protected carboxyl terminus that can be used to control reactivity during synthesis and subsequent coupling steps. Structurally, it provides a flexible, hydrophilic chain that can span the distance between a target-binding ligand and an E3 ligase recruiter, reducing steric clashes and helping maintain productive ternary complex formation. In PROTAC workflows, the azide handle enables efficient attachment via azide–alkyne cycloaddition (CuAAC or SPAAC) or related click chemistries, allowing modular assembly of degraders under mild conditions. The tert-butyl ester offers synthetic utility by masking a carboxylic acid until deprotection, improving coupling selectivity. This linker is valuable for researchers optimizing linker length, flexibility, and conjugation chemistry to tune degradation potency and selectivity in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Popular Publications Citing BOC Sciences Products
Azido-PEG12-Boc is a PEG-based bifunctional linker designed for modular PROTAC assembly, enabling robust spatial separation between a ligand and an E3-recruiting or target-binding warhead. Its azide handle supports bioorthogonal conjugation, while the Boc-protected functionality offers controlled reactivity during synthetic sequencing. These features facilitate the preparation of well-defined degraders with improved coupling efficiency and tunable linker length/solvation. The structure and reactivity considerations are described in detail below.
Structure: The linker contains a poly(ethylene glycol) chain that provides conformational flexibility and enhanced aqueous compatibility. It incorporates an azide functional group for click-type coupling and a Boc-protected moiety that masks a reactive amine equivalent until deprotection. The framework includes ether linkages typical of PEG, alongside carbamate-related functionality from the Boc group.
Reactivity: Azido-PEG12-Boc is commonly used as an azide partner in copper-catalyzed azide–alkyne cycloaddition or related azide conjugation strategies, where the azide reacts with an appropriately functionalized alkyne under conditions compatible with PEG stability. The Boc group is typically removed using acid-mediated deprotection to reveal the corresponding amine for subsequent coupling steps. Selection of solvents and bases should prioritize solubility of PEG conjugates and minimize side reactions during sequential linker installation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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