Name: Azido-PEG3-t-butyl ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO (10 mm)

Appearance

Pale Yellow or Colorless Oily Matter

Application

Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.<br />Monodisperse Azido-PEG3-t-butyl ester (N3-PEG3-CH2CH2COOtBu) is a click chemistry reagent containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

ShelfLife

0-4°C for short term (days to weeks), or -20°C for long term (months).

Storage

Store at -20°C, keep in dry and avoid sunlight

Shipping

Room temperature

IUPACName

tert-butyl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate

Synonyms

N3-PEG3-CH2CH2COOtBu;N3-PEG3-tBu; N3-PEG3-CH2CH2-Boc; 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester; tert-Butyl 12-azido-4,7,10-trioxadocecanoate; 12-Azido-4,7,10-trioxadodecanoic acid tert-butyl ester; 2-Methyl-2-propanyl 3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanoate; Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

InChI Key

QUSLQIYNPWASRR-UHFFFAOYSA-N

InChI

InChI=1S/C13H25N3O5/c1-13(2,3)21-12(17)4-6-18-8-10-20-11-9-19-7-5-15-16-14/h4-11H2,1-3H3

SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCN=[N+]=[N-]

Azido-PEG3-t-butyl ester is a PEG-based, azide-bearing PROTAC linker designed to enable modular assembly of targeted protein degraders through bioorthogonal click chemistry and subsequent functionalization. Its ether-rich PEG scaffold provides conformational flexibility and improved solubility, while the terminal azide offers a reliable handle for conjugation to ligands or warheads. The t-butyl ester functionality supports controlled downstream derivatization. Detailed structural and reactivity considerations are provided below.

Structure: The linker contains an azide functional group attached to a short polyethylene glycol chain and terminates in a t-butyl ester. It features ether linkages characteristic of PEG, an ester carbonyl, and an azide moiety suitable for cycloaddition. Overall, it is an organic, polar, and chemically stable scaffold.

Reactivity: The azide group is well suited for strain-promoted or copper-catalyzed azide–alkyne cycloaddition to connect PROTAC components under mild conditions. The ester can be transformed via base-promoted deprotection to generate a carboxylate for amide coupling to ligands. Typical workflows use compatible polar organic solvents, inert atmospheres when needed, and standard coupling reagents for stepwise PROTAC synthesis.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂