Azido-PEG7-alcohol
CAS No.: 1274892-60-2
Cat No.: BP-500270
Purity: >95%
4.5 
Azido-PEG7-alcohol is a heterobifunctional polyethylene glycol linker bearing a terminal azide group and a hydroxyl group, providing a flexible, hydrophilic spacer of intermediate chain length. The azide functionality enables chemoselective conjugation via copper-catalyzed or strain-promoted azide–alkyne cycloaddition (click chemistry), allowing researchers to attach the linker to complementary alkyne-bearing ligands such as small-molecule targeting moieties or to other PROTAC components under mild conditions. The PEG backbone improves solubility, reduces nonspecific hydrophobic interactions, and helps maintain productive geometry between the recruited target-binding ligand and the E3 ligase-recruiting element, which is critical for efficient ternary complex formation and subsequent ubiquitination. In targeted protein degradation research, this linker is valuable for constructing modular PROTACs and related degraders, facilitating systematic optimization of linker length and attachment position while supporting robust aqueous handling during synthesis and biological evaluation.
Structure of 1274892-60-2
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Azido-PEG7-alcohol is a PEG-based linker bearing a terminal azide functionality, designed to support modular assembly of targeted protein degradation (PROTAC) constructs. Its flexible poly(ethylene glycol) segment helps tune linker length and conformational freedom, while the azide enables robust bioorthogonal conjugation strategies. This product is widely useful for preparing PROTAC intermediates where orthogonal functional handles are required; the following sections describe its structure and the practical reactivity considerations for PROTAC synthesis in detail below.
Structure: The linker is composed of a poly(ethylene glycol) chain terminated with an azide group and a terminal alcohol. It contains ether linkages along the PEG backbone and a primary alcohol, providing hydrophilicity and conformational flexibility. The azide moiety offers a reactive handle for subsequent coupling.
Reactivity: The azide group is compatible with azide–alkyne cycloaddition chemistry and related click-style conjugation approaches, enabling attachment to complementary alkyne-bearing partners under mild conditions. Typical workflows employ copper(I) catalysis with appropriate ligands and polar organic solvents, or copper-free variants using strained cyclooctynes to minimize metal effects. The alcohol can be functionalized via standard derivatization routes (e.g., activation to form leaving groups) to facilitate PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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