Azido-PEG36-acid
Cat No.: BP-501953
4.5 
Azido-PEG36-acid is a polyethylene glycol (PEG) linker bearing a terminal azide functionality and a carboxylic acid group, providing a flexible, water-compatible chain of extended length suitable for bioconjugation. The azide handle enables bioorthogonal click chemistry (typically copper-catalyzed or strain-promoted azide–alkyne cycloaddition) to connect the linker to complementary PROTAC modules such as ligands bearing an alkyne or cyclooctyne motif. The terminal acid allows additional coupling strategies, including amide bond formation to attach the linker to amine-containing targeting or E3-recruiting components, or to introduce controlled attachment points for further derivatization. In PROTAC design, this dual-reactive architecture helps tune spatial separation and local flexibility between the two binding elements, which can improve productive ternary complex formation and thereby influence targeted protein degradation efficiency. The long PEG segment also often enhances aqueous solubility and reduces nonspecific hydrophobic interactions, supporting robust experimental workflows in targeted degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG36-acid is a polyethylene glycol-based linker bearing a terminal azide and a carboxylic acid, designed to support modular PROTAC assembly. Its flexible PEG scaffold helps decouple the binding elements, while the azide handle enables efficient conjugation to complementary partners under bioorthogonal conditions. The carboxylic acid provides a practical functional group for coupling strategies, facilitating systematic optimization of targeted protein degradation constructs. Detailed structural and reactivity considerations are provided below.
Structure: The molecule consists of a long, flexible PEG chain terminated by an azide group and a carboxylic acid. The linker contains ether linkages along the PEG backbone and an aliphatic carboxyl functionality. This combination yields high conformational flexibility and strong hydrophilicity, supporting solvent-compatible PROTAC synthesis.
Reactivity: The azide group is well suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling selective attachment to alkyne-functional ligands. The carboxylic acid can be activated for amide or ester bond formation using standard coupling chemistries (e.g., carbodiimide-based activation with appropriate bases). Reactions are typically performed under mild, anhydrous conditions compatible with sensitive targeting ligands, with solvent systems chosen to maintain solubility of both partners.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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