Azido-PEG36-Boc
Cat No.: BP-501821
4.5 
Azido-PEG36-Boc is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a protected carboxyl functionality (Boc) at the opposite end. Structurally, it comprises a long, flexible PEG chain that provides hydrophilicity, reduced nonspecific binding, and spatial separation between conjugated partners, while the azide enables efficient bioorthogonal “click” chemistry (typically copper-catalyzed or strain-promoted azide–alkyne cycloaddition) for modular attachment to alkyne-bearing ligands. In PROTAC and targeted protein degradation workflows, this linker is used to tune the distance and relative orientation between the target-binding ligand and the E3 ligase-recruiting module, thereby optimizing formation of the ternary complex and improving degradation performance. The Boc-protected terminus offers a convenient handle for downstream deprotection and further functionalization, facilitating iterative linker–warhead engineering. Overall, Azido-PEG36-Boc is valuable for researchers seeking robust, chemically versatile PEG spacers to systematically explore linker length and conjugation strategies in degradation assays.
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG36-Boc is a PEG-based bifunctional linker designed for modular construction of PROTACs, enabling efficient conjugation between a ligand and an E3-recruiting warhead. Its flexible poly(ethylene glycol) scaffold supports favorable linker conformations and improved solubility, while the azide handle provides a widely used chemical “click” site for orthogonal attachment. The tert-butyl ester-protected carboxyl group provides a protected acid handle that can be unmasked under controlled conditions. Detailed structural and synthetic considerations are provided below.
Structure: The linker contains a long, flexible PEG chain that confers hydrophilicity and conformational adaptability, coupled to an azide functional group and a tert-butyl ester-protected carboxyl group. Key features include ether linkages along the PEG backbone and an azide substituent suitable for bioorthogonal cycloaddition.
Reactivity: Azido-PEG36-Boc is typically incorporated into PROTAC assemblies via azide participation in copper-catalyzed azide–alkyne cycloaddition or related azide-based conjugation strategies, using an appropriate alkyne partner. The tert-butyl ester is commonly cleaved under acid-mediated conditions to generate the carboxylic acid for subsequent coupling reactions. After deprotection, the carboxylic acid can be activated for standard amide coupling with an amine-containing partner using compatible bases and coupling reagents in suitable organic solvents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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