Azido-PEG5-triethoxysilane
Cat No.: BP-501724
Purity: 98%
4.5 
Azido-PEG5-triethoxysilane is a heterobifunctional PEG-based linker that combines a terminal azide group with a triethoxysilane moiety. Structurally, it features an ether-rich PEG chain of intermediate length that provides aqueous solubility and conformational flexibility, while the azide enables bioorthogonal conjugation via azide–alkyne cycloaddition (CuAAC or strain-promoted variants) to attach PROTAC-relevant ligands or handles. In parallel, the triethoxysilane group can undergo hydrolysis and condensation to form stable siloxane linkages on silica or other hydroxylated inorganic surfaces, allowing immobilization or surface-mediated organization of PROTAC components. In targeted protein degradation research, this linker is valuable for constructing modular degradation platforms, such as surface-anchored or multicomponent assemblies where precise spatial positioning can enhance effective recruitment and proximity between the E3 ligase binder and the target-binding ligand.
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* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
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| ConcentrationVolumeMass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8563 mL | 9.2814 mL | 18.5629 mL |
| 5 mM | 0.3713 mL | 1.8563 mL | 3.7126 mL |
| 10 mM | 0.1856 mL | 0.9281 mL | 1.8563 mL |
Azido-PEG5-triethoxysilane is a bifunctional PEG-based linker designed for modular PROTAC synthesis, combining an azide handle for bioorthogonal conjugation with a trialkoxysilane group for stable surface or polymer attachment. Its flexible ethylene glycol spacer supports productive geometry between ligands, while the silane functionality enables robust tethering under sol–gel compatible conditions. The detailed structure and reactivity guidance are provided below.
Structure: The molecule contains a terminal azide for click-type coupling and a PEG spacer that imparts conformational flexibility. A triethoxysilane moiety provides hydrolyzable alkoxy groups attached to silicon, enabling formation of siloxane linkages. The overall scaffold is ether-rich and relatively hydrophilic.
Reactivity: The azide group is typically used in copper(I)-catalyzed azide–alkyne cycloaddition or in strain-promoted azide chemistry, depending on the complementary partner. The triethoxysilane portion reacts through hydrolysis and condensation, generally promoted by controlled moisture and mild acid or base catalysis, forming Si–O–Si bonds. Common solvents include alcohol/water mixtures for silane activation, while click steps are performed in compatible organic media with appropriate catalysts and inert atmosphere when required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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