Azido-PEG7-azide
CAS No.: 225523-86-4
Cat No.: BP-501435
Purity: >95%
4.5 
Azido-PEG7-azide is a symmetric homobifunctional polyethylene glycol linker bearing azide groups at both termini, providing a flexible, water-soluble chain length suitable for PROTAC and related targeted protein degradation constructs. Structurally, it consists of an oligo(ethylene glycol) backbone that separates conjugated ligands, reducing steric interference and helping preserve binding affinity at each end while maintaining overall solubility. In PROTAC design, this linker enables modular assembly through azide chemistry: one azide terminus can be coupled to an alkyne-functional ligand (e.g., via copper-catalyzed or strain-promoted azide–alkyne cycloaddition), while the second azide has the same click reactivity and can be conjugated in a subsequent controlled step to another compatible alkyne-bearing component. Its value lies in providing controlled spatial presentation of two binding elements, facilitating ternary complex formation and improving the practical workflow for synthesizing degraders that require precise, reproducible linker architecture for structure–activity relationship studies.
Structure of 225523-86-4
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Azido-PEG7-azide is a bifunctional polyethylene glycol linker designed for modular construction of PROTACs, enabling efficient conjugation of two ligating fragments through azide-reactive handles. Its PEG-based scaffold provides conformational flexibility and aqueous compatibility, which can improve productive ternary complex formation and overall degradation performance. The structure and reactivity considerations for PROTAC synthesis and linker installation are described in detail below.
Structure: Azido-PEG7-azide contains a PEG oligomer backbone terminated with azide groups, providing flexible ether-rich spacing and terminal N3 functionalities. The linker features ether linkages within the polymer chain and azide moieties at both ends, supporting hydrophilicity and solubility in polar media.
Reactivity: The terminal azides are suitable for bioorthogonal “click” conjugation, most commonly via copper-catalyzed azide–alkyne cycloaddition with appropriate alkyne partners, or via strain-promoted azide–alkyne cycloaddition using cyclooctyne derivatives. Typical conditions employ inert atmosphere compatibility, controlled copper loading for CuAAC, and polar solvents such as aqueous or mixed aqueous systems; reaction efficiency depends on azide accessibility and alkyne reactivity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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