Benzyl-PEG11-alcohol
Cat No.: BP-501752
Purity: ≥95%
4.5 
Benzyl-PEG11-alcohol is a polyethylene glycol (PEG) linker bearing a benzyl ether terminus and a terminal primary alcohol, providing a long, flexible hydrophilic chain suitable for conjugation chemistry. Structurally, it combines an aromatic benzyl group with an extended PEG segment and a reactive hydroxyl handle, enabling attachment to PROTAC-related warheads, ligands, or solubilizing motifs through standard functional group transformations (e.g., esterification, ether formation, or conversion of the alcohol to an activated derivative). In PROTAC design, PEG linkers are widely used to tune spatial separation, reduce steric hindrance, and improve aqueous solubility, thereby facilitating productive ternary complex formation between the target-binding ligand and the E3 ligase recruiter. The long chain length and conformational flexibility can help maintain binding competence while optimizing degradation efficiency across different linker architectures. This reagent is therefore valuable for constructing and screening targeted protein degradation conjugates with improved physicochemical properties and controllable linker geometry.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Benzyl-PEG11-alcohol is a PEG-based linker alcohol designed for constructing PROTACs and other bifunctional degraders where controlled spacing and aqueous compatibility are essential. Its flexible poly(ethylene glycol) segment can reduce steric interference between the target-binding ligand and the E3-recruiting moiety, supporting efficient ternary complex formation. The benzyl terminus provides a convenient handle for downstream functionalization, and the alcohol enables straightforward derivatization. Detailed structural and reactivity considerations are provided below.
Structure: The molecule comprises a benzyl group attached to a long, flexible poly(ethylene glycol) chain terminating in a primary alcohol. Ether linkages along the PEG backbone impart hydrophilicity and conformational flexibility, while the benzylic aromatic ring contributes chemical stability and a functional benzyl terminus for coupling.
Reactivity: As a primary alcohol, it can be converted into activated intermediates for PROTAC assembly, commonly via esterification or ether formation using standard coupling chemistries. Suitable approaches include forming carbonate or mesylate-type leaving groups followed by nucleophilic substitution with ligand-bearing nucleophiles. Mild base-promoted conditions and polar organic solvents are typically used to preserve sensitive functional groups and maintain linker integrity during conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
