Benzyl-PEG4-N3
CAS No.: 86770-71-0
Cat No.: BP-501091
Purity: ≥95%
4.5 
Benzyl-PEG4-N3 is a benzyl-capped polyethylene glycol linker bearing a terminal azide (N3) functionality, providing a flexible, water-compatible chain of defined length suitable for bioconjugation workflows. In PROTAC and related targeted protein degradation architectures, such PEG linkers are commonly used to spatially separate a ligand-binding warhead from an E3-recruiting moiety, reducing steric clashes and helping maintain productive ternary complex formation. The terminal azide enables chemoselective conjugation through azide-reactive click chemistries (for example, copper-catalyzed or strain-promoted azide–alkyne cycloaddition), allowing researchers to attach the linker to complementary handles on partner fragments under mild conditions. Its PEG character also improves solubility and can modulate linker hydrophilicity, which is advantageous for handling, formulation, and comparative structure–activity studies. Overall, Benzyl-PEG4-N3 is a practical building block for constructing PROTACs with tunable geometry and reliable synthetic connectivity.
Structure of 86770-71-0
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Benzyl-PEG4-N3 is a PEG-based PROTAC linker featuring a benzyl terminus and an azide functional group, enabling modular conjugation to targeting ligands and E3-recruiting moieties. Its polyethylene glycol segment provides conformational flexibility and improved solubility, which can help maintain productive ternary-complex formation in targeted protein degradation workflows. The structure and reactivity considerations for constructing PROTACs using this linker are described in detail below.
Structure: The linker comprises a benzyl group connected through a polyethylene glycol chain to a terminal azide. It contains ether linkages within the PEG segment and a carbon–nitrogen azide functionality, offering a flexible, polar scaffold with good aqueous compatibility and chemical stability under typical organic synthesis conditions.
Reactivity: The terminal azide is well suited for copper-catalyzed azide–alkyne cycloaddition or related azide-based conjugation strategies to assemble PROTAC constructs. Typical conditions employ an appropriate alkyne partner, a copper catalyst system, and compatible solvents that support solubility of both coupling components. The reaction proceeds via azide activation and cycloaddition to form a stable triazole linkage, enabling efficient, modular synthesis while preserving functional group integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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