Benzyl-PEG6-amine
CAS No.: 86770-78-7
Cat No.: BP-501226
Purity: >95%
4.5 
Benzyl-PEG6-amine is a polyethylene glycol–based linker bearing a benzyl group at one terminus and a primary amine at the other, providing a flexible, hydrophilic spacer of about six ethylene glycol units. Its ether-rich PEG backbone improves solubility and reduces nonspecific hydrophobic interactions, while the terminal amine enables straightforward conjugation chemistry to connect this spacer to ligands used in PROTACs or other targeted degradation constructs. In PROTAC design, such linkers help position the two functional modules—typically a target-binding ligand and an E3 ligase recruiter—at an appropriate distance and orientation to promote formation of the ternary complex. The benzyl end can serve as a convenient hydrophobic handle for attachment or as part of a linker region that modulates local microenvironment. This reagent is valuable for constructing and optimizing PROTACs where linker flexibility, aqueous compatibility, and reliable functional-group reactivity are critical for measurable degradation activity.
Structure of 86770-78-7
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Benzyl-PEG6-amine is a polyethylene glycol–based PROTAC linker building block designed to provide conformational flexibility, improved solubility, and a chemically addressable amine handle for bioconjugation. Its ether-rich PEG segment can help tune linker length and hydrophilicity, which are key variables in targeted protein degradation workflows. The following sections describe its structure and practical reactivity considerations for PROTAC assembly in research settings.
Structure: The linker comprises a benzyl group attached to a poly(ethylene glycol) chain terminated by a primary amine. It contains multiple ether linkages along the PEG backbone and a benzylic carbon–carbon bond to the aromatic ring, yielding a flexible, hydrophilic scaffold suitable for conjugation chemistry.
Reactivity: The terminal primary amine enables standard PROTAC coupling strategies such as amide formation with activated carboxylic acids (for example, using carbodiimide/acid-activator systems) or urea/amide linkages via isocyanate or activated ester intermediates. Reactions are typically performed under inert or controlled atmospheres with polar aprotic solvents, and mild base conditions are commonly used to promote nucleophilic acyl substitution while preserving functional-group compatibility.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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