Benzyl-PEG8-NHS ester
Cat No.: BP-501817
4.5 
Benzyl-PEG8-NHS ester is a PEG-based heterobifunctional linker featuring a benzyl-protected terminus and an N-hydroxysuccinimide (NHS) ester at the opposite end, enabling stable amide-bond formation with primary amines. The structure consists of a benzyl group linked to an eight-unit polyethylene glycol chain, providing a flexible, hydrophilic spacer that can reduce steric interference and improve solubility of conjugates. In PROTAC design, this linker is used to connect an amine-bearing targeting ligand or protein-recruiting moiety to an NHS-reactive handle, thereby positioning the two components at an appropriate distance and orientation to support ternary-complex formation and subsequent ubiquitin–proteasome–mediated degradation. Its PEG spacer can also help mitigate nonspecific hydrophobic interactions and facilitate aqueous handling during synthesis and assay development. Overall, Benzyl-PEG8-NHS ester is a practical, widely used reagent for constructing modular targeted degradation probes and optimizing linker length and attachment chemistry.
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* For research and manufacturing use only. Not for human or clinical use.
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Benzyl-PEG8-NHS ester is a PEG-based linker designed for efficient conjugation in PROTAC assembly workflows. Its NHS-ester functionality enables rapid, chemoselective coupling to primary amines on targeting ligands, while the PEG spacer provides improved solubility and conformational flexibility that can support productive ternary complex formation. The features and practical considerations for its use in targeted protein degradation experiments are described in detail below.
Structure: The molecule comprises a benzyl group attached to a polyethylene glycol chain terminating in an N-hydroxysuccinimide ester. It contains an activated carboxylate within the NHS ester, ether linkages along the PEG backbone, and stable C–C and C–O bonds, yielding a polar, water-compatible scaffold.
Reactivity: NHS esters typically undergo nucleophilic acyl substitution with primary amines to form stable amide bonds. For PROTAC linker conjugation, reactions are commonly performed under mildly basic aqueous or mixed aqueous/organic conditions using amine-containing ligands as nucleophiles. The NHS ester is moisture-sensitive, so fresh solutions and controlled pH are important; catalysts are generally not required, and unreacted ester is removed by standard purification.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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