Benzyl-PEG8-t-butyl ester
Cat No.: BP-501738
Purity: ≥95%
4.5 
Benzyl-PEG8-t-butyl ester is a polyethylene glycol linker bearing a benzyl group at one terminus and a tert-butyl ester at the other, providing an eight-unit PEG chain that confers aqueous solubility and conformational flexibility. The benzyl substituent can be used as a hydrophobic handle for controlled attachment or purification strategies, while the tert-butyl ester serves as an acid-labile functional group that enables ester-to-acid conversion under appropriate conditions, facilitating downstream coupling to PROTAC warheads or ligands. In PROTAC design, PEG linkers are widely used to spatially separate the two binding elements, reducing steric clashes and improving productive formation of the ternary complex between the target protein binder and the E3 ligase recruiter. This linker’s length and ether-rich backbone help maintain favorable linker dynamics, which can enhance degradation efficiency and reproducibility across different conjugate architectures.
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* For research and manufacturing use only. Not for human or clinical use.
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Benzyl-PEG8-t-butyl ester is a PEG-based PROTAC linker designed to provide a flexible, solvent-compatible spacer between a ligand and a recruited target-binding module. Its ether-rich polyethylene glycol segment supports conformational mobility, while the ester handles enable modular attachment strategies commonly used in targeted protein degradation workflows. The linker’s design facilitates efficient synthesis and subsequent functionalization; the detailed structural and reactivity considerations are provided below.
Structure: The linker contains a polyethylene glycol chain terminated by a benzyl group and a tert-butyl ester. It features multiple ether linkages that confer hydrophilicity and conformational flexibility, along with an ester functional group suitable for controlled chemical transformations.
Reactivity: The benzyl and tert-butyl ester functionalities enable orthogonal, stepwise synthesis of PROTAC intermediates. Ester formation and subsequent deprotection can be achieved using standard acylation and acid-mediated or base-assisted conditions, respectively, depending on the protecting group strategy. Typical coupling steps employ activated carboxylic acid derivatives, while solvents such as polar aprotic media and inert atmosphere are often used to maintain compatibility with PEG ethers and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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