Bis-Mal-PEG11
Cat No.: BP-501917
4.5 
Bis-Mal-PEG11 is a homobifunctional polyethylene glycol linker featuring two maleimide termini attached to a long PEG chain, providing flexible spacing and aqueous solubility while enabling thiol-reactive conjugation. The maleimide groups undergo rapid, selective Michael addition with accessible cysteine thiols on peptide or protein ligands, allowing researchers to couple two biomolecular components or to install two attachment points on a single targeting moiety. In PROTAC and targeted protein degradation workflows, such bis-maleimide PEG linkers are valuable for engineering multivalent architectures, tuning effective molar ratios and spatial orientation between the ligand-binding module and the E3 ligase-recruiting element, and improving conjugate stability in biological buffers. The PEG11 length helps reduce steric constraints and can enhance productive ternary complex formation by increasing linker compliance. Overall, Bis-Mal-PEG11 supports robust, reproducible synthesis of thiol-functionalized PROTACs and related degraders for mechanistic and optimization studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Bis-Mal-PEG11 is a bifunctional polyethylene glycol linker designed for constructing PROTACs through efficient conjugation to ligand scaffolds. Its dual maleimide termini enable selective attachment to suitable thiol-bearing partners, supporting modular synthesis and flexible optimization of linker length and solubility. Such linkers are widely used in targeted protein degradation workflows to tune degrader architecture and improve handling of conjugates; the following points describe the structure and practical reactivity considerations in detail.
Structure: The linker comprises a PEG backbone that provides hydrophilicity and conformational flexibility, terminated by two maleimide groups. It contains stable ether linkages along the polymer chain and electrophilic cyclic imide functionalities, enabling controlled nucleophilic addition chemistry under mild conditions.
Reactivity: Maleimides react with thiols via a Michael-type addition to form stable thioether adducts. PROTAC assembly typically uses thiol-containing ligands under near-neutral, aqueous-compatible conditions to preserve maleimide reactivity and minimize side reactions. Common approaches employ buffered solvents such as phosphate or similar aqueous buffers, with careful control of thiol stoichiometry and pH; catalysts are generally unnecessary for the conjugation step.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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