Bis-(N,N'-carboxyl-PEG4)-Cy5
CAS No.: 2107273-44-7
Cat No.: BP-500890
Purity: 98%
4.5 
Bis-(N,N'-carboxyl-PEG4)-Cy5 is a Cy5 fluorescent dye conjugated to two carboxyl-terminated, PEG4-based linker arms, providing a flexible, hydrophilic spacer while retaining reactive handles for bioconjugation. Structurally, the molecule contains the cyanine chromophore core (Cy5) for far-red optical readout and two polyethylene glycol chains terminated with carboxyl groups, enabling amide coupling or other carboxyl-reactive chemistries to attach the dye to PROTAC scaffolds, targeting ligands, or carrier proteins. In PROTAC design, such dual-linker architectures are valuable for installing a traceable reporting group without strongly perturbing the binding pharmacophores, as the PEG spacers can reduce steric interference and improve aqueous solubility. The resulting conjugates facilitate quantitative monitoring of synthesis, cellular uptake, localization, and degradation kinetics in targeted protein degradation workflows, supporting optimization of linker length, conjugation site, and overall construct performance.
Structure of 2107273-44-7
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker product, Bis-(N,N'-carboxyl-PEG4)-Cy5, combines a fluorescent Cy5 scaffold with PEG-based spacer arms terminated by carboxyl functionalities. The flexible, water-compatible PEG segments support productive ternary complex formation and improve solubility, while the Cy5 label enables tracking of conjugation and degradation-related workflows. The subsequent points describe the linker’s structural features and practical reactivity for constructing PROTACs in a research setting.
Structure: The molecule features a Cy5 chromophore conjugated to two PEG4-based arms bearing terminal carboxylic acid groups. Its structure includes ether linkages within the PEG spacers, amide-capable carbonyls, and aromatic/heteroaromatic components typical of cyanine dyes, providing amphiphilic, water-soluble character.
Reactivity: The terminal carboxyl groups are suited for amide-bond formation with primary or secondary amines commonly used in PROTAC synthesis. Typical coupling approaches rely on carbodiimide-mediated activation (often with additive bases) in polar aprotic solvents, followed by nucleophilic acyl substitution to form stable amide linkages. Maintaining controlled pH and minimizing hydrolysis are important for reproducible conjugation efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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