Bis-PEG11-acid
CAS No.: 2097010-30-3
Cat No.: BP-500979
Purity: >97%
4.5 
Bis-PEG11-acid is a bifunctional polyethylene glycol linker featuring two terminal carboxylic acid groups separated by long PEG11 chains, providing a flexible, water-soluble spacer for PROTAC construction. Structurally, the extended PEG segments reduce steric congestion and help maintain productive geometry between the ligand-binding “warhead” moieties and the recruited E3 ligase ligand when assembled into a conjugate. In PROTAC design, this type of bis-PEG linker can mediate effective intramolecular proximity by allowing conformational adaptability, thereby improving the likelihood of ternary complex formation and promoting ubiquitination-dependent targeted protein degradation. The two carboxyl termini enable straightforward coupling to amine- or hydrazide-functional partners via standard amide or related coupling chemistries, facilitating modular synthesis and systematic linker-length optimization. Overall, Bis-PEG11-acid is valuable for researchers aiming to tune linker flexibility and hydrophilicity to enhance degradation potency and experimental robustness in targeted degradation studies.
Structure of 2097010-30-3
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Bis-PEG11-acid is a PEG-based bifunctional linker designed to support PROTAC assembly by providing two compatible attachment handles while maintaining favorable solubility and conformational flexibility. Its hydrophilic PEG architecture can help reduce nonspecific interactions and support efficient conjugate formation, enabling robust targeted protein degradation workflows.
Structure: Bis-PEG11-acid is a bis(ethylene glycol)–derived linker featuring repeating ether units that impart hydrophilicity and chain flexibility. It contains carboxylic acid functionalities suitable for amide or related coupling chemistry, with stable C–O and C–C framework bonds and no inherently reactive ring systems.
Reactivity: The carboxylic acid groups are typically activated for PROTAC bond formation using standard peptide-coupling strategies, such as carbodiimide-based or uronium-based activation, often with an amine-bearing ligand partner. Reactions are commonly performed under controlled pH and inert or low-water conditions to minimize side reactions. Suitable solvents include polar aprotic media or buffered aqueous-organic mixtures, depending on ligand stability; coupling proceeds via formation of an activated ester/intermediate followed by nucleophilic acyl substitution.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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