Name: Baricitinib
Brand: BOC Sciences
Price: 199 USD
Availability: MadeToOrder

Size

Price

Stock

Quantity

1 g

$199

In stock

Purity

>98%

Appearance

White to Off-white Solid

Application

the treatment of rheumatoid arthritis (RA)

Synonyms

LY3009104; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; Olumiant

Boiling Point

707.2±70.0 °C at 760 mmHg

Melting Point

212-215°C

Density

1.6±0.1 g/cm3

InChI Key

XUZMWHLSFXCVMG-UHFFFAOYSA-N

InChI

InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

Canonical SMILES

CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

1.Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate.

Keystone EC1, Taylor PC2, Drescher E3, Schlichting DE4, Beattie SD4, Berclaz PY4, Lee CH4, Fidelus-Gort RK5, Luchi ME5, Rooney TP4, Macias WL4, Genovese MC6. Ann Rheum Dis. 2015 Feb;74(2):333-40. doi: 10.1136/annrheumdis-2014-206478. Epub 2014 Nov 27.

OBJECTIVES: To investigate baricitinib (LY3009104, formerly INCB028050), a novel, oral inhibitor of JAK1/JAK2 in patients with moderate to severe rheumatoid arthritis (RA) despite treatment with methotrexate.

2.Baricitinib in Patients with Refractory Rheumatoid Arthritis.

Genovese MC1, Kremer J1, Zamani O1, Ludivico C1, Krogulec M1, Xie L1, Beattie SD1, Koch AE1, Cardillo TE1, Rooney TP1, Macias WL1, de Bono S1, Schlichting DE1, Smolen JS1. N Engl J Med. 2016 Mar 31;374(13):1243-52. doi: 10.1056/NEJMoa1507247.

BACKGROUND: In phase 2 studies, baricitinib, an oral Janus kinase 1 and 2 inhibitor, reduced disease activity in patients with rheumatoid arthritis who had not previously received treatment with biologic disease-modifying antirheumatic drugs (DMARDs).

3.Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib.

Jabbari A1, Dai Z1, Xing L2, Cerise JE1, Ramot Y3, Berkun Y4, Sanchez GA5, Goldbach-Mansky R5, Christiano AM6, Clynes R7, Zlotogorski A3. EBioMedicine. 2015 Feb 26;2(4):351-5. doi: 10.1016/j.ebiom.2015.02.015. eCollection 2015.

BACKGROUND: Alopecia areata (AA) is an autoimmune disease resulting in hair loss with devastating psychosocial consequences. Despite its high prevalence, there are no FDA-approved treatments for AA. Prior studies have identified a prominent interferon signature in AA, which signals through JAK molecules.

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.6924 mL	13.4618 mL	26.9237 mL
5 mM	0.5385 mL	2.6924 mL	5.3847 mL
10 mM	0.2692 mL	1.3462 mL	2.6924 mL
50 mM	0.0538 mL	0.2692 mL	0.5385 mL

HPLC

HNMR

Dear sir. Can Baricitinib cross the blood-brain barrier in mice?

Yeah! Within a mouse model of HIV-associated neurocognitive impairment (HAND), Baricitinib crossed the blood-brain barrier and significantly reduced HIV-induced neuroinflammation marked by glial activation.

19/2/2016

Can Baricitinib inhibit allergen-induced airway eosinophilia in a mouse model?

Yes. In a mouse model of acute house dust mite-induced airway inflammation in BALB/c mice, Baricitinib effectively induced apoptosis and inhibited eosinophil chemotaxis and respiratory burst.

6/3/2018

Good afternoon, what is the biological activity of Baricitinib? Thanks.

Baricitinib preferentially inhibits JAK1 and JAK2 in a low nanomolar range, which in turn reduces the signaling of a variety of cytokines and growth factors.

22/7/2022

block the phosphorylation of STAT3

We treated the isolated T cells with Baricitinib to significantly inhibit IL-23-stimulated pSTAT3 and inhibit the production of two pathogenic cytokines (IL-17 and IL-22) by Th17 cells (helper T cell subtypes with obvious inflammatory and pathogenic characteristics).

9/2/2022

reduce the inflammation response

Our H&E staining and immunohistochemistry experiments showed that the Baricitinib-treated arthritis mouse model exhibited significantly reduced inflammation, reduced CD8 infiltration, and reduced MHC class I and II expression.

9/2/2022

inhibit pulmonary fibrosis

By immunohistochemistry, Western blot and MTT assay, we observed that Baricitinib inhibited the proliferation and migration of lung fibroblasts by inhibiting TGF-β1 signaling pathway, and finally effectively attenuated bleomycin (BLM) -induced pulmonary fibrosis in mice.

9/2/2022

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂