Boc-C5-O-C5-O-C6-Cl

 CAS No.: 1835705-52-6  Cat No.: BP-500001 4.5  

Boc-C5-O-C5-O-C6-Cl is an alkyl–ether PROTAC linker building block containing flexible hydrocarbon segments, internal ether linkages, a chloroalkyl attachment handle, and a protected carboxyl-derived terminus. These structural features provide both hydrophobic spacing and moderate conformational flexibility, while the chloro group can support nucleophilic substitution with suitable ligand or recruiter intermediates. In PROTAC linker design, this product is useful for constructing degrader analogues that require a mixed alkyl–ether spacer to tune the distance and orientation between a target-binding ligand and an E3 ligase-recruiting ligand. It supports linker optimization, attachment-site evaluation, and structure–activity relationship studies in targeted protein degradation research.

Boc-C5-O-C5-O-C6-Cl

Structure of 1835705-52-6

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Category
PROTAC Linker
Molecular Formula
C21H41ClO4
Molecular Weight
393

* For research and manufacturing use only. Not for human or clinical use.

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Solubility
10 mM in DMSO
Storage
Pure form<br/>-20°C<br/>3 years<br/><br/><br/> <br/>4°C<br/>2 years<br/><br/><br/>In solvent<br/>-80°C<br/> 6 months<br/><br/><br/> <br/>-20°C<br/>1 month
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Room temperature in continental US; may vary elsewhere
Synonyms
Boc-C5-O-C5-O-C6-Cl; PROTAC Linker 2; tert-butyl 6-[5-(6-chlorohexoxy)pentoxy]hexanoate
InChI Key
BCFCLXINSZPNKH-UHFFFAOYSA-N
InChI
InChI=1S/C21H41ClO4/c1-21(2,3)26-20(23)14-8-6-11-17-25-19-13-7-12-18-24-16-10-5-4-9-15-22/h4-19H2,1-3H3
SMILES
CC(C)(C)OC(=O)CCCCCOCCCCCOCCCCCCCl

Boc-C5-O-C5-O-C6-Cl is a protected alkyl-ether linker used as a hydrophobic and flexible spacer in PROTAC linker design. Its tert-butyl ester protection and chloroalkyl terminus support staged functionalization for assembling degrader intermediates. The structure and reactivity features are described below.

Structure: The linker contains an aliphatic chain, ether bonds, a tert-butyl ester-protected carboxylate motif, and a terminal alkyl chloride. It is non-aromatic, conformationally flexible, and relatively hydrophobic compared with PEG-rich linkers.

Reactivity: The alkyl chloride can undergo nucleophilic substitution with amines, thiols, alkoxides, or azides in polar aprotic solvents with appropriate base. The tert-butyl ester can be removed under acidic conditions to reveal a carboxylic acid for amide or ester coupling. This orthogonal reactivity supports sequential PROTAC linker installation.

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: (2S,4R)-4-hydroxy-N-[(1S)-3-(methylamino)-3-oxo-1-phenylpropyl]-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]pyrrolidine-2-carboxamide | (2S,4R)-N-[(1S)-1-(4-cyanophenyl)-3-(methylamino)-3-oxopropyl]-4-hydroxy-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]pyrrolidine-2-carboxamide | Pmd-PEG3-BI | 14,14,14-Trifluoro-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate | 3,6,9,12,15,18,21,24,27,30-Decaoxahentriacontanoic acid | 17-(Fmoc-amino)-5-oxo-6-aza-3,9,12,15-tetraoxaheptadecanoic Acid | 3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione | 4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne | Pomalidomide-PEG3-C2-NH2 (TFA) | 1-Phenyl-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl 4-methylbenzenesulfonate | Boc-C5-O-C5-O-C6-Cl

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