Boc-HyNic-PEG1-mal
Cat No.: BP-501782
4.5 
Boc-HyNic-PEG1-mal is a heterobifunctional PEG-based linker designed for PROTAC and related targeted protein degradation workflows. Structurally, it combines a Boc-protected hydrazinonicotinamide (HyNic) handle with a short, one-unit polyethylene glycol spacer and a terminal maleimide group, providing a defined linkage architecture that is compatible with common conjugation chemistries. In PROTAC assembly, the maleimide enables chemoselective coupling to thiol-bearing ligands (for example, cysteine- or thiol-functionalized targeting moieties), while the HyNic moiety can be used to form stable hydrazone linkages with aldehyde-functional partners under standard conjugation conditions. The PEG spacer helps modulate solubility and spatial presentation, which can improve productive engagement between the targeting ligand and the E3 ligase recruiting module. This linker is valuable for researchers seeking modular, efficient synthesis of degradation constructs with controlled geometry and reduced steric constraints, facilitating systematic structure–activity studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Boc-HyNic-PEG1-mal is a bifunctional PEG-based linker designed for constructing PROTACs via reliable, chemoselective coupling strategies. Its protected HyNic motif and terminal maleimide enable controlled conjugation to thiol-bearing ligands, supporting efficient formation of ternary-complex degraders. The PEG segment provides conformational flexibility and improved solubility, which can be advantageous for maintaining productive linker–ligand geometry in targeted protein degradation workflows. Detailed structural and reactivity considerations are provided below.
Structure: The linker combines a Boc-protected hyNic-derived functionality with a short polyethylene glycol spacer and a maleimide electrophile. It contains amide and carbamate linkages, an ether-rich PEG segment, and a conjugated maleimide double bond suitable for Michael-type addition. Overall, it is expected to be water-compatible due to the PEG chain.
Reactivity: PROTAC assembly with this linker typically relies on thiol–maleimide chemoselective conjugation, where a ligand bearing a free sulfhydryl performs a nucleophilic addition to the maleimide under mild aqueous or mixed aqueous conditions. Reaction progress is commonly monitored by analytical methods, and pH is selected to preserve maleimide reactivity while maintaining thiol availability. The Boc-protecting group is generally handled through standard deprotection steps when required for downstream functionalization.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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