Br-PEG3-ethyl acetate
CAS No.: 308085-31-6
Cat No.: BP-501348
4.5 
Br-PEG3-ethyl acetate is a bromo-terminated, short-chain polyethylene glycol linker bearing an ethyl acetate functional handle. Structurally, it provides a flexible PEG spacer that can improve solubility and reduce steric constraints between a ligand-binding moiety and a reactive conjugation site, while the terminal bromide enables chemoselective attachment to nucleophilic partners through substitution or related coupling strategies. In PROTAC design, such bifunctional linkers are used to connect the target-binding ligand and the E3-recruiting ligand (or other functional fragments) with an appropriate linker length and geometry, thereby facilitating productive ternary complex formation and efficient ubiquitination. The PEG3 segment helps maintain conformational mobility, which is often critical for tuning degradation potency and selectivity across different protein targets. This linker is therefore valuable for constructing modular PROTACs and for systematic linker optimization in targeted protein degradation research.
Structure of 308085-31-6
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Br-PEG3-ethyl acetate is a polyethylene glycol (PEG)-based PROTAC linker building block designed to connect ligands through a bromine-activated handle and a PEG spacer, enabling efficient formation of targeted protein degraders. Its flexible, hydrophilic PEG segment can improve solubility and support productive ternary-complex formation in PROTAC workflows. The subsequent points describe its structural features and practical reactivity considerations for linker installation and PROTAC assembly.
Structure: The linker combines a PEG chain segment with an ethyl acetate motif and a terminal bromine functionality. It contains ether linkages within the PEG region and an ester linkage in the acetate portion, providing a balance of flexibility, polarity, and chemical stability under typical organic synthesis conditions.
Reactivity: The terminal bromine enables nucleophilic substitution or coupling strategies commonly used to append PROTAC ligands, with conditions selected to preserve PEG integrity and avoid ester hydrolysis. Suitable approaches include base-promoted substitution using appropriate nucleophiles, and coupling reactions where bromine serves as an electrophilic leaving group. Mild solvents and controlled temperatures are typically used; catalysts are reaction-dependent and should be chosen to maintain linker stability and compatibility with ligand functional groups.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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