Br-PEG3-THP
CAS No.: 220568-33-2
Cat No.: BP-501239
Purity: ≥95%
4.5 
Br-PEG3-THP is a bromide-terminated, three-unit polyethylene glycol (PEG) linker incorporating a tetrahydropyranyl (THP)-protected alcohol, designed to provide a flexible, hydrophilic spacer for PROTAC construction. The PEG segment confers conformational mobility and improved solubility, helping the recruited ligands access productive geometries for ternary complex formation. The terminal bromide enables chemoselective conjugation to nucleophilic functional groups on either the targeting ligand or the E3 ligase-recruiting moiety, while the THP group protects an alcohol that can be revealed by deprotection for later functionalization and maintaining overall linkage integrity under typical synthetic conditions. In targeted protein degradation research, such linkers are valuable for tuning linker length and flexibility to optimize ubiquitination efficiency and degradation potency while reducing nonspecific aggregation. This reagent is therefore useful for systematic PROTAC optimization and for generating well-defined, modular conjugates for mechanistic studies.
Structure of 220568-33-2
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Br-PEG3-THP is a functionalized polyethylene glycol-based linker designed for constructing PROTACs via modular conjugation. Its bromo-terminated handle and THP-protected functionality enable controlled assembly of targeted degradation constructs, supporting reliable linker installation and subsequent coupling to ligands. The PEG segment provides favorable solubility and conformational flexibility, which can improve the practical performance of PROTAC architectures. Detailed structural and synthetic considerations are provided below.
Structure: Br-PEG3-THP features an ether-rich PEG chain that confers hydrophilicity and segmental flexibility, capped with a brominated reactive terminus and a THP-protected group. The molecule contains multiple C–O ether linkages and a halogen substituent, with a polar, conformationally adaptable scaffold suitable for bioconjugation workflows.
Reactivity: The brominated terminus is suitable for nucleophilic substitution or related coupling strategies commonly used to connect PROTAC components under standard organic synthesis conditions. THP-protected functionality is typically manipulated using mild deprotection approaches when required, enabling stepwise assembly. Selection of compatible bases, nucleophiles, and solvents should follow established ether/halide coupling practices to preserve ligand integrity and minimize side reactions during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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