Bromo-PEG3-azide
CAS No.: 1446282-43-4
Cat No.: BP-501071
Purity: ≥95%
4.5 
Bromo-PEG3-azide is a bifunctional polyethylene glycol linker featuring a terminal bromo group and an azide handle separated by a short PEG chain, providing a flexible, hydrophilic spacer suitable for modular PROTAC assembly. In PROTAC design, the bromo terminus acts as an electrophile in nucleophilic substitution with a suitable nucleophilic partner, while the azide group enables efficient bioorthogonal conjugation (most commonly via copper-catalyzed or strain-promoted azide–alkyne cycloaddition) to attach the second molecular component. The PEG3 segment helps reduce steric clashes, improves solubility, and can tune the effective distance and orientation between the target-binding ligand and the E3 ligase-recruiting moiety, which are critical determinants of ternary complex formation and degradation potency. This linker is therefore valuable for researchers seeking to rapidly generate and compare PROTAC architectures with controlled spacing and reliable, orthogonal functional-group chemistry.
Structure of 1446282-43-4
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Bromo-PEG3-azide is a bifunctional polyethylene glycol (PEG) linker designed for modular assembly of PROTACs, enabling orthogonal attachment strategies to ligands that require either azide-based conjugation or electrophilic handle reactivity. Its PEG spacer supports productive ternary complex formation by improving solubility and offering conformational flexibility, while the azide and bromo functionalities facilitate controlled, stepwise linker-to-ligand coupling. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a PEG-based polyether chain providing hydrophilicity and flexible spacing, together with an azide group and a bromo substituent on the terminal positions. It features ether linkages along the PEG backbone and a terminal carbon–halogen bond suitable for substitution chemistry.
Reactivity: The azide group is compatible with copper-catalyzed azide–alkyne cycloaddition for installing an alkyne-bearing ligand under standard click conditions. The bromo handle can be used for nucleophilic substitution with appropriate nucleophiles (e.g., amines or thiols) to form C–N or C–S bonds, typically in polar aprotic solvents. Stepwise coupling is commonly used to preserve orthogonality and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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