Bromo-PEG6-t-butyl ester
CAS No.: 1393330-41-0
Cat No.: BP-501418
Purity: >95%
4.5 
Bromo-PEG6-t-butyl ester is a heterobifunctional PEG-based linker designed for PROTAC and targeted protein degradation workflows, featuring a terminal bromo leaving group for chemoselective substitution and a protected carboxyl group as a t-butyl ester for controlled conjugation. The PEG6 chain provides a hydrophilic, flexible spacer that reduces steric interference between the recruited target-binding ligand and the E3-ligase-binding moiety, while maintaining sufficient conformational freedom for productive ternary complex formation. In PROTAC construction, the bromo terminus can be used to install the linker onto nucleophilic partners (e.g., via substitution or subsequent functional group interconversion), and the ester functionality can be retained during assembly and later unmasked under appropriate conditions to enable amide or related bond formation. This linker value lies in its modularity and spacer properties, supporting systematic optimization of linker length and attachment chemistry to improve degradation efficiency and experimental reproducibility.
Structure of 1393330-41-0
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Bromo-PEG6-t-butyl ester is a PEG-based, bromo-functional linker designed for modular PROTAC synthesis, enabling efficient conjugation between a ligand and a reactive partner while maintaining favorable solubility and conformational flexibility. Its ether-rich polyethylene glycol scaffold helps reduce steric constraints and supports productive ternary-complex formation in targeted protein degradation workflows. The bromo handle and protected carboxylate functionality are particularly useful for stepwise assembly; detailed structural and reactivity considerations are provided below.
Structure: The linker contains a polyethylene glycol chain bearing a terminal bromo substituent and a tert-butyl ester-protected carboxylate. It features ether linkages along the PEG backbone, a carbon–bromine bond at the reactive terminus, and an ester carbonyl that is stable under mild conditions but readily removable under acidic or transesterification conditions.
Reactivity: The bromo group is suitable for nucleophilic substitution or coupling strategies commonly used in PROTAC linker installation, including reactions with amines or organometallic nucleophiles under conditions that preserve ester integrity. The tert-butyl ester can be deprotected to reveal a carboxylic acid for subsequent amide or ester bond formation. Typical approaches employ polar aprotic solvents and base or acid catalysts selected to balance substitution efficiency with minimal side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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