Amino-PEG4-t-butyl ester
CAS No.: 581065-95-4
Cat No.: BP-501093
Purity: >95%
4.5 
Amino-PEG4-t-butyl ester is a polyethylene glycol linker featuring an amine terminus and a protected carboxyl group masked as a tert-butyl ester. Structurally, it provides a short, flexible PEG chain that increases aqueous solubility and reduces steric interference between PROTAC-binding ligands, while the terminal amine enables straightforward conjugation to activated carboxylates or electrophiles for assembling bifunctional degraders. In PROTAC designs, PEG linkers act as molecular “spacers” that tune the effective geometry and distance between the target-binding moiety and the E3 ligase ligand, thereby improving productive ternary complex formation and degradation efficiency. The tert-butyl ester functionality is commonly used as a temporary protection strategy during synthesis, allowing selective deprotection to generate a reactive carboxyl handle for final coupling. This linker is valuable for constructing modular, water-compatible PROTACs and for systematic optimization of linker length and polarity in targeted protein degradation research.
Structure of 581065-95-4
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Amino-PEG4-t-butyl ester is a PEG-based PROTAC linker building block designed to provide controlled spacing, aqueous compatibility, and flexible conformational behavior between ligands. Its protected carboxyl functionality enables selective downstream conjugation strategies commonly used in targeted protein degradation workflows. The linker’s hydrophilic PEG segment can improve solubility and reduce nonspecific interactions, supporting efficient assembly of bifunctional degraders. Detailed structural and reactivity guidance is provided below.
Structure: Amino-PEG4-t-butyl ester contains a PEG chain segment providing hydrophilicity and conformational flexibility, paired with an amino handle for coupling and a tert-butyl ester protecting group on the carboxyl functionality. The molecule features ether linkages within the PEG backbone and standard amide/ester-forming reactive motifs.
Reactivity: The tert-butyl ester is typically used as a protected carboxyl group that can be deprotected under acid-promoted conditions to generate a free carboxylic acid for subsequent amide bond formation. PROTAC assembly commonly employs carboxyl activation and nucleophilic coupling with an amine-bearing partner, using coupling reagents and compatible solvents to preserve PEG integrity. Reaction planning should consider maintaining aqueous compatibility and minimizing PEG oxidation or hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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