m-PEG23-alcohol
Cat No.: BP-501901
4.5 
m-PEG23-alcohol is a methoxy-terminated, middle-chain poly(ethylene glycol) (PEG) alcohol featuring an ether-rich, flexible hydrophilic spacer with a terminal primary alcohol suitable for chemical functionalization. In PROTAC architectures, PEG linkers are widely used to tune the effective distance and conformational freedom between the target-binding ligand and the E3-ligase recruiter, thereby improving the probability of productive ternary complex formation. The ether oxygen atoms can also modulate local solvation and reduce non-specific hydrophobic interactions, which is beneficial for maintaining solubility and experimental handling of conjugates. As a linker building block, this PEG alcohol can be converted into activated derivatives for coupling reactions, enabling systematic linker-length and polarity optimization in targeted protein degradation studies. Its well-defined, extended chain supports rational exploration of how linker geometry influences degradation potency, kinetics, and overall physicochemical properties of PROTAC candidates.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG23-alcohol is a polyethylene glycol (PEG) linker designed for PROTAC assembly, providing a hydrophilic, conformationally flexible spacer that can improve solubility and modulate the effective distance and orientation between a ligand and an E3-recruiting moiety. Its alcohol handle enables straightforward functionalization under standard synthetic conditions, facilitating the preparation of linker–ligand conjugates used in targeted protein degradation workflows. The following sections describe the structure and practical reactivity considerations in detail below.
Structure: m-PEG23-alcohol is a PEG-based, ether-rich chain terminating in a primary alcohol. The repeating ethylene glycol units provide flexible C–O and C–C connectivity, while the terminal hydroxyl offers a reactive functional group. The linker is generally water-compatible and exhibits low polarity barriers due to extensive ether oxygen atoms.
Reactivity: The terminal alcohol can be converted into PROTAC-compatible coupling partners via standard derivatization of primary alcohols, enabling formation of ether, ester, or carbonate linkages depending on the chosen electrophile. Typical approaches use activating reagents in polar aprotic solvents with base to promote nucleophilic substitution or acylation. Reaction design should consider preserving ligand integrity and maintaining solubility of intermediates during conjugation and purification steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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