Bromoacetamido-PEG2-acid

 CAS No.: 1415800-44-0  Cat No.: BP-500346  Purity: ≥95% 4.5  

Bromoacetamido-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Bromoacetamido-PEG2-acid

Structure of 1415800-44-0

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Category
PROTAC Linker
Molecular Formula
C9H16BrNO5
Molecular Weight
298.13
Appearance
Pale Yellow Oily Liquid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
Appearance
Pale Yellow Oily Liquid
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
3-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]propanoic acid
Synonyms
BrCH2CONH-PEG2-acid; Bromoacetamido-PEG2-C2-acid; 3-(2-(2-(2-Bromoacetamido)ethoxy)ethoxy)propanoic acid; Bromoacetamido-PEG2-CH2CH2COOH; Propanoic acid, 3-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]-
Boiling Point
491.4±45.0 °C at 760 mmHg
Density
1.5±0.1 g/cm3
InChI Key
PIANHFIJCGRNCU-UHFFFAOYSA-N
InChI
InChI=1S/C9H16BrNO5/c10-7-8(12)11-2-4-16-6-5-15-3-1-9(13)14/h1-7H2,(H,11,12)(H,13,14)
Canonical SMILES
C(COCCOCCNC(=O)CBr)C(=O)O

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It is commonly abbreviated as: C1V1 = C2V2

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Historical Records: Propargyl-PEG4-Br | Cbz-N-amido-PEG5-acetic acid | endo-BCN-PEG3-mal | mPEG16-alcohol | endo-BCN-PEG4-acid | Boc-aminooxy-PEG5-propargyl | N-(m-PEG4)-N'-(amino-PEG3)-Cy5 | Propargyl-PEG6-thiol | Bis(NHS)PEG5 | ANB-NOS | Bromoacetamido-PEG2-acid

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