Propargyl-PEG24-amine
Cat No.: BP-501726
Purity: >95%
4.5 
Propargyl-PEG24-amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group (alkyne handle) and a primary amine at the opposite end, connected through a long PEG chain that provides high aqueous solubility and conformational flexibility. In PROTAC and targeted protein degradation designs, this linker serves as a modular spacer that can tune the effective distance and orientation between the ligand-bearing “warhead” and the recruitment module, thereby improving productive ternary complex formation and degradation efficiency. The propargyl functionality enables chemoselective conjugation via copper-catalyzed azide–alkyne cycloaddition (CuAAC) to attach to azide-functional partners, while the amine allows alternative coupling strategies such as amide-bond formation with activated carboxylic acids or other electrophiles. Its extended, hydrophilic PEG architecture helps reduce nonspecific interactions and aggregation, supporting robust synthesis and reliable performance in biochemical assays.
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* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
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| ConcentrationVolumeMass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.8990 mL | 4.4950 mL | 8.9901 mL |
| 5 mM | 0.1798 mL | 0.8990 mL | 1.7980 mL |
| 10 mM | 0.0899 mL | 0.4495 mL | 0.8990 mL |
Propargyl-PEG24-amine is a polyethylene glycol (PEG)-based PROTAC linker designed to provide a hydrophilic, conformationally flexible spacer between a warhead and an E3 ligase ligand. Its terminal propargyl group enables chemoselective conjugation strategies, while the primary amine supports robust attachment chemistry for constructing targeted protein degraders. The linker’s PEG character can improve aqueous compatibility and help tune effective linker length and dynamics in ternary-complex formation. Detailed structural and synthetic considerations are provided below.
Structure: The molecule comprises a PEG chain terminating in a propargyl (alkyne) functionality and a primary amine. It contains repeating ether linkages that confer flexibility and hydrophilicity, alongside a carbon–carbon triple bond and an amine capable of forming salts and participating in coupling reactions.
Reactivity: The terminal alkyne supports click-type conjugations (commonly copper-catalyzed azide–alkyne cycloaddition) to connect to azide-bearing partners under mild conditions. The primary amine enables amide or urea formation via standard coupling chemistries, typically using activated carboxylic acids or isocyanates, with base and polar aprotic solvents. Reaction design should consider orthogonality between alkyne and amine functionalities and preserve linker integrity during PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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