BTK-IN-24

 CAS No.: 2649400-34-8  Cat No.: BP-400195  Purity: 98% by HPLC 4.5  

BTK-IN-24 is a novel oral small molecule that induces BTK degradation via recruitment of the cereblon E3 ubiquitin ligase complex. BTK-IN-24 induces sub-nanomolar potency degradation of both wild-type and known mutant forms of BTK in vitro, demonstrating rapid in vivo degradation in mouse and non-human primate B cells within two hours of oral administration.

BTK-IN-24

Structure of 2649400-34-8

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PROTAC
Molecular Formula
C42H54N12O5
Molecular Weight
807.0
Appearance
Off-white to Light Yellow Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
98% by HPLC
Appearance
Off-white to Light Yellow Solid
IUPACName
3-[4-[1-[[1-[6-[[(3S)-2,6-dioxopiperidin-3-yl]carbamoyl]pyridin-3-yl]piperidin-4-yl]methyl]piperidin-4-yl]anilino]-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]pyrazine-2-carboxamide
Synonyms
NX-5948; NX 5948; NX5948
InChI Key
HPTPDBYCFHFWJG-CWTKIQHKSA-N
InChI
InChI=1S/C42H54N12O5/c1-50-21-22-54(42(50)59)32-3-2-16-53(26-32)35-24-45-37(38(43)56)39(48-35)46-30-6-4-28(5-7-30)29-14-17-51(18-15-29)25-27-12-19-52(20-13-27)31-8-9-33(44-23-31)40(57)47-34-10-11-36(55)49-41(34)58/h4-9,23-24,27,29,32,34H,2-3,10-22,25-26H2,1H3,(H2,43,56)(H,46,48)(H,47,57)(H,49,55,58)/t32-,34+/m1/s1
Canonical SMILES
CN1CCN(C1=O)C2CCCN(C2)C3=CN=C(C(=N3)NC4=CC=C(C=C4)C5CCN(CC5)CC6CCN(CC6)C7=CN=C(C=C7)C(=O)NC8CCC(=O)NC8=O)C(=O)N

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L

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: Tos-PEG3-NH-Boc | Pomalidomide-PEG1-C2-NH2 | BTK-IN-24

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